CAJ | 학술논문

目的：探讨中国汉族人群精神分裂症阳性症状患者与5-羟色胺2A受体基因T102C多态性之间的关系。　方法：采用AmP-RFLP方法，检测精神分裂症患者和对照组的5-HT2A受体基因频率分布。结果：精神分裂症阳性症状患者5-HT2A受体基因型频率、等位基因频率与对照组无明显差异，但有精神病家族史精神分裂症患者A1A1基因型频率， A1等位基因频率明显高于对照组。　结论：实验结果提示，5-HT 2A受体基因多态性与有精神病家族史的精神分裂症阳性症状患者密切相关，A1等位基因可能是精神分裂症发病的风险基因之一。
목적：탐토중국한족인군정신분렬증양성증상환자 여5-간색알2A수체기인T102C다태성지간적관계。　방법： 채용AmP-RFLP방법，검측정신분렬증환자화대조조적5-HT2A수체기인빈솔분포。결과：정신분렬증양성증상환자5-HT2A수체기인형빈솔、등 위기인빈솔여대조조무명현차이，단유정신병가족사정신분렬증환자A1A1기인형빈솔， A1등위기인빈솔명현고우대조조。　결론：실험결과제시，5-HT 2A수체기인다태성여유정신병가족사적정신분렬증양성증상환자밀절상관，A1등위 기인가능시정신분렬증발병적풍험기인지일。
Objective:To explore the association between gene polymorphism of serotonin A (5-HT2A) receptor and schizophrenia with posi tive symptoms.　Method:The gene polymorphism of 5-HT2A re ceptor was determined in positive schizophrenic cases and normal controls with a mplification restriction fragment length polymorphism (AmP-RFLP) technique.　Results:The frequencies of A1A1 genetype and A1 allele were higher in schizophrenia with positive history than in controls. No differences w ere found in the frequencies of 5-HT2A receptor genetype and allele gene between two groups.　Conclusion:The 5-HT2A receptor gene polymorphism may be associated with schizophrenic patients who have positive fam ily history.