CAJ | 학술논문

首次合成了侧链带有手性基团的聚半胱氨酸-b-聚环氧丙烷-b-聚半胱氨酸嵌段共聚物.首先炔丙基溴和L-半胱氨酸反应,合成了S-炔丙基-L-半胱氨酸,产物与三光气反应,合成S-炔丙基-N-羧基-L-半胱氨酸-环内酸酐(NCA);然后用大分子引发剂双端氨基聚环氧丙烷引发S-炔丙基-N-羧基-L-半胱氨酸-环内酸酐(NCA)开环聚合,制得了聚环氧丙烷-聚(S-炔丙基-L-半胱氨酸)嵌段共聚物;最后由N_3-L-亮氨酸与共聚物侧链上的炔键发生Click反应,制得了侧链连有手性基团的嵌段共聚物.用~1H NMR、IR、GPC和元素分析等方法对所得嵌段聚合物结构进行了表征.
수차합성료측련대유수성기단적취반광안산-b-취배양병완-b-취반광안산감단공취물.수선결병기추화L-반광안산반응,합성료S-결병기-L-반광안산,산물여삼광기반응,합성S-결병기-N-최기-L-반광안산-배내산항(NCA);연후용대분자인발제쌍단안기취배양병완인발S-결병기-N-최기-L-반광안산-배내산항(NCA)개배취합,제득료취배양병완-취(S-결병기-L-반광안산)감단공취물;최후유N_3-L-량안산여공취물측련상적결건발생Click반응,제득료측련련유수성기단적감단공취물.용~1H NMR、IR、GPC화원소분석등방법대소득감단취합물결구진행료표정.
A novel chiral block copolymer PCys-b-PPO-b-PCys bearing Leucine in the side chain was synthesized for the first time.Using propyl bromide and L-cysteine reagent as raw materials,S-propyl-L-cysteine was synthesized.S-propargyl-L-cysteine-N-carboxy anhydride (NCA) was prepared by the reaction of S-propyl-L-cysteine and triphosgene.The PCys-b-PPO-b-PCys was synthesized with poly(propylene glycol) bis (2-aminopropyl ether) as macromolecular initiator for the ring-opening polymerization of NCA.At last amphiphilic block copolymer bearing Leucine in the side chain was synthesized by the Click reaction of PCys-b-PPO-b-PCys and α-azido-L-leucine.The structure and composition of the copolymers were characterized by IR,~1H NMR,GPC and elemental analysis.