国际生物制品学杂志
國際生物製品學雜誌
국제생물제품학잡지
INTERNATIONAL JOURNAL OF BIOLOGICALS
2010年
2期
76-79
,共4页
HIV感染%静电作用%抑制,化学性%精液源性病毒感染增强因子%前列腺酸性磷酸酶
HIV感染%靜電作用%抑製,化學性%精液源性病毒感染增彊因子%前列腺痠性燐痠酶
HIV감염%정전작용%억제,화학성%정액원성병독감염증강인자%전렬선산성린산매
HIV infections%Electrostatic interactions%Depression,chemical%Semen-derived enhancer of viral infection%Prostatic acid phosphatase
人精液前列腺酸性磷酸酶(prostatic acid phosphatase,PAP)多肽片段形成的淀粉样原纤维具有促进人类免疫缺陷病毒(human immunedeficiency virus,HIV)感染的作用,这些原纤维被称为精液源性病毒感染增强因子(semen-derived enhancer of viral infection,SEVI),其中PAP第248-286位多肽片段(PAP248-286)促进HIV感染的作用最强.具有阳离子特性的SEVI可通过静电作用捕获HIV颗粒而促进HIV感染.近期研究报道,SEVI对异嗜性小鼠白血病病毒相关病毒感染也有增强作用,可能与前列腺癌发生有关.某些多聚阴离子化合物和绿茶多酚成分能明显抑制SEVI活性.研究SEVI生物学特性及其功能对于HIV等病毒感染的防治具有重要意义.
人精液前列腺痠性燐痠酶(prostatic acid phosphatase,PAP)多肽片段形成的澱粉樣原纖維具有促進人類免疫缺陷病毒(human immunedeficiency virus,HIV)感染的作用,這些原纖維被稱為精液源性病毒感染增彊因子(semen-derived enhancer of viral infection,SEVI),其中PAP第248-286位多肽片段(PAP248-286)促進HIV感染的作用最彊.具有暘離子特性的SEVI可通過靜電作用捕穫HIV顆粒而促進HIV感染.近期研究報道,SEVI對異嗜性小鼠白血病病毒相關病毒感染也有增彊作用,可能與前列腺癌髮生有關.某些多聚陰離子化閤物和綠茶多酚成分能明顯抑製SEVI活性.研究SEVI生物學特性及其功能對于HIV等病毒感染的防治具有重要意義.
인정액전렬선산성린산매(prostatic acid phosphatase,PAP)다태편단형성적정분양원섬유구유촉진인류면역결함병독(human immunedeficiency virus,HIV)감염적작용,저사원섬유피칭위정액원성병독감염증강인자(semen-derived enhancer of viral infection,SEVI),기중PAP제248-286위다태편단(PAP248-286)촉진HIV감염적작용최강.구유양리자특성적SEVI가통과정전작용포획HIV과립이촉진HIV감염.근기연구보도,SEVI대이기성소서백혈병병독상관병독감염야유증강작용,가능여전렬선암발생유관.모사다취음리자화합물화록다다분성분능명현억제SEVI활성.연구SEVI생물학특성급기공능대우HIV등병독감염적방치구유중요의의.
Amyloid fibrils formed by the peptides of prostatic acid phosphatase (PAP) in human semen proves to enhance human immunodeficiency virus (HIV) infection, and these fibrils are termed semen-derived enhancer of viral infection (SEVI). The peptide fragments containing 248 to 286 amino acid residues of PAP (PAP248-286) in SEVI are most effective to enhance HIV infection. SEVI with cationic properties can directly bind to HIV particles through electrostatic interactions, thus increasing HIV infection. Recently, it is reported that SEVI also boosts xenotropic murine leukemia virus-related virus infection which may be associated with prostate cancer. Some of the polyanionic compounds and the main green tea polyphenol can inhibit SEVI activity obviously. Study on the biological properties and effects of SEVI should be of great significance for prevention and treatment of HIV and other viral infections.
