CAJ | 학술논문

目的了解我院住院患者临床分离的念珠菌分布及耐药现状.方法收集近两年我院临床分离的念珠菌,测定常用抗真菌药物的敏感性.结果两年内分别分离出念珠菌585株和1030株,分离率分别为11.76%和16.21%.白色念珠菌是最常见的分离菌,但热带念珠菌分离率上升.受检药物均有较高的抗菌活性,仅克柔念珠菌对氟康唑的耐药率分别为66.7%和77.1%,剂量依赖性敏感的比例分别为16.7%和20.0%.结论白色念珠菌仍是分离出最常见的念珠菌,其次为热带念珠菌,建议白色念珠菌和热带念珠菌感染时使用氟康唑,克柔念珠菌感染者应用伊曲康唑.
목적 료해아원주원환자림상분리적념주균분포급내약현상.방법 수집근량년아원림상분리적념주균,측정상용항진균약물적민감성.결과 량년내분별분리출념주균585주화1030주,분리솔분별위11.76%화16.21%.백색념주균시최상견적분리균,단열대념주균분리솔상승.수검약물균유교고적항균활성,부극유념주균대불강서적내약솔분별위66.7%화77.1%,제량의뢰성민감적비례분별위16.7%화20.0%.결론 백색념주균잉시분리출최상견적념주균,기차위열대념주균,건의백색념주균화열대념주균감염시사용불강서,극유념주균감염자응용이곡강서.
Objective To investigate the epidemiology of clinical isolated Candida and their etiology resistance.Methods All strains of etiological Candida isolated from the inpatients of the hospital in the recent two years were collected.The susceptibility of usual antifungal drugs was analyzed.Results 585 and 1030 strains of Candida were isolated in the two years,the rate was 11.76%and 16.21%respectively.Candida albicans was the most common Candida,but Candida tropicalis increased in the second year.Most of the antifungal drugs kept high sensitive to Candida,only 66.7%and 77.1%of Candida kruser was resistant to fluconazole,16.7%and 20.0%was dose-depended sensitive to fluconazole.Conclusions Candida albicans is still the most common Candida in clinic,followed by Candida tropicalis.So fluconazole is suggested to be used in infections caused by Candida albicans or Candida tropicalis,and itraconazole in Candida kruser infection.