CAJ | 학술논문

[目的]观察自制防晒乳膏的防晒指数SPF值和PFA值.[方法]体外法测定样品防晒指数:将样品以2μl/cm2的剂量涂抹于仿生皮肤3M膜上,然后用防晒指数测定仪测定样品的防晒指数.豚鼠在体防晒指数的测定:白化豚鼠48只,随机分为8组,其中4组不涂防晒样品,4组分别涂布自制防晒乳膏和对照样品(某市售防晒制剂),使用SUV-1000型日光紫外线模拟器模拟紫外线照射,测定样品防晒指数.[结果]体外法检测自制防晒乳膏和某市售制剂的SPF值分别为32.26±2.42和30.87±2.57,PFA值分别是24.28±2.44和17.53±2,28,两种制剂SPF相比,t=0.94,P＞0.05(n=5)；但自制防晒乳膏对UVA的防护效果优于某市售制剂,t=4.52,P＜ 0.01(n=5).豚鼠在体法检测自制防晒乳膏和某市售制剂的SPF值分别为30.39±6.65和28.79±7.36,PFA＞ 8.91和＞8.93,两种制剂SPF值比较,f=0.38,P＞ 0.05(n=12).[结论]自制防晒乳膏和某市售制剂相比,对紫外线的防护效果相当.
[목적]관찰자제방쇄유고적방쇄지수SPF치화PFA치.[방법]체외법측정양품방쇄지수:장양품이2μl/cm2적제량도말우방생피부3M막상,연후용방쇄지수측정의측정양품적방쇄지수.돈서재체방쇄지수적측정:백화돈서48지,수궤분위8조,기중4조불도방쇄양품,4조분별도포자제방쇄유고화대조양품(모시수방쇄제제),사용SUV-1000형일광자외선모의기모의자외선조사,측정양품방쇄지수.[결과]체외법검측자제방쇄유고화모시수제제적SPF치분별위32.26±2.42화30.87±2.57,PFA치분별시24.28±2.44화17.53±2,28,량충제제SPF상비,t=0.94,P＞0.05(n=5)；단자제방쇄유고대UVA적방호효과우우모시수제제,t=4.52,P＜ 0.01(n=5).돈서재체법검측자제방쇄유고화모시수제제적SPF치분별위30.39±6.65화28.79±7.36,PFA＞ 8.91화＞8.93,량충제제SPF치비교,f=0.38,P＞ 0.05(n=12).[결론]자제방쇄유고화모시수제제상비,대자외선적방호효과상당.
[Objective] To determine the sun protection factor (SPF) and protection factor of ultraviolet A (PFA) of a self-made sunscreen cream.[Methods] The sample of a self-made sunscreen cream and a commercial sunscreen cream were painted to an artificial skin (3M film) at a dose of 2 μl/cm2,and a tester was used to evaluate their photoprotective effect.A total of 48 albinism guinea pigs were classified into 8 groups to remain unprotected or be protected by the self-made or commercial sunscreen cream.A solar ultraviolet light simulator (SUV-1000) was used to simulate the ultraviolet rays in sunlight to irradiate the guinea pigs,and the photoprotecfive effect of these sunscreen creams was determined.[Results] The in vitro evaluation revealed that the SPF value of the self-made sun-screen cream and commercial cream was 32.26 ± 2.42 and 30.87 ± 2.57respectively (n =5,t =0.94,P ＞ 0.05),and the PFA value was 24.28 ± 2.44 and 17.53 ± 2.28 respectively (n =5,t =4.52,P＜ 0.01 ).As the in vivo experiment showed,the SPF value of the self-made sun-screen cream and commercial cream was 30.39 ± 6.65 and 28.79 ± 7.36,respectively (n =12,t =0.38,P＞ 0.05),and the PFA value was ＞ 8.91 and ＞ 8.93 respectively.[Conclusion] The photoprotective effect of the self-made sunscreen cream is similar to that of the commercial cream.