CAJ | 학술논문

目的调查运动诱发气道痉挛( EIB)和特应质之间的关系.方法采取整群抽样的方法选取北京市城区和郊区各1所中学学生,利用运动筛查试验的方法调查EIB的发生率,通过血清总IgE水平和皮肤过敏原点刺结果判断特应质,根据支气管激发试验判断气道高反应性.将发生EIB的学生(EIB组)与正常学生(对照组)进行配对分析,均接受皮肤过敏原点刺、血清总IgE水平测定和支气管激发试验,利用相关分析方法判断EIB和特应质的关系,分析EIB学生气道高反应的发生情况.结果共773名10～13岁学生(男389名,女384名)参加研究,其中89名学生(EIB组,男43名、女46名)运动筛查试验阳性,EIB发生率为11.5％ (89/773)；EIB组89名学生中,16人血清总IgE水平和皮肤过敏原点刺结果超过正常上限,对照组70名学生中,10人血清总IgE水平和皮肤过敏原点刺结果超过正常上限.通过x2检验发现,特应质与EIB之间无明显相关；50名接受支气管激发试验的EIB组学生中,只有1名呈阳性结果.结论特应质与EIB发病无明显相关.绝大多数EIB学生不存在气道高反应.
목적 조사운동유발기도경련( EIB)화특응질지간적관계.방법 채취정군추양적방법선취북경시성구화교구각1소중학학생,이용운동사사시험적방법조사EIB적발생솔,통과혈청총IgE수평화피부과민원점자결과판단특응질,근거지기관격발시험판단기도고반응성.장발생EIB적학생(EIB조)여정상학생(대조조)진행배대분석,균접수피부과민원점자、혈청총IgE수평측정화지기관격발시험,이용상관분석방법판단EIB화특응질적관계,분석EIB학생기도고반응적발생정황.결과 공773명10～13세학생(남389명,녀384명)삼가연구,기중89명학생(EIB조,남43명、녀46명)운동사사시험양성,EIB발생솔위11.5％ (89/773)；EIB조89명학생중,16인혈청총IgE수평화피부과민원점자결과초과정상상한,대조조70명학생중,10인혈청총IgE수평화피부과민원점자결과초과정상상한.통과x2검험발현,특응질여EIB지간무명현상관；50명접수지기관격발시험적EIB조학생중,지유1명정양성결과.결론 특응질여EIB발병무명현상관.절대다수EIB학생불존재기도고반응.
Objective To investigate the correlation between exercise-induced bronchoconstriction and atopy.Methods Exercise-induced bronchoconstriction (EIB) was defined by free running asthma screening test.Atopy was defined by serum total IgE level and skin allergen test.Airway hyperreactivity was determined by bronchial provocation test.For a matched pair study,all EIB and some non-EIB students received serum total IgE measurements,skin allergen test and bronchial provocation test. All data were calculated by correlation analysis to investigate the correlation between EIB and atopy.Results Totally 773students participated in the free running screening test,and 89 students (11.5％) were diagnosed as having EIB.The serum total IgE level exceeded the normal range in 16 among the 89 EIB students,but in 10 among the 70 non- EIB students.Statistical analysis (x2 test) did not support the correlation between atopy and EIB.Fifty EIB students received bronchial provocation test,but only 1 showed airway hyperreactivity.Conclusion There was no correlation between atopy and EIB,and airway hyperreactivity was absent in most of the EIB students.