CAJ | 학술논문

目的分析原发乳腺非霍奇金淋巴瘤(PNHLB)的临床特点与预后.方法回顾性分析45例PNHLB的临床特点.5例行乳房改良根治术,5例行患侧乳房单纯切除术.43例行CHOP或CHOP样联合化疗,其中6例加用利妥昔单抗.19例化疗后行局部放疗,1例仅行单纯放疗.45例患者均获随访,随访时间6～180个月.结果 45例PNHLB患者中,弥漫大B细胞性淋巴瘤(DLBCL)37例,T细胞型淋巴瘤4例,黏膜相关淋巴组织样淋巴瘤(MALT)4例.一线化疗的有效率为90.7%.中位总生存期(OS)为6.82年,中位无进展生存期(PFS)为4.25年.Cox比例风险模型分析结果显示,IPI(RR=5.682,P=0.002)、Ann Arbor分期(RR=1.836,P=0.040)是PNHLB患者OS的独立影响因素,中枢神经系统浸润(RR=1.107,P=0.005)是PFS的独立影响因素.结论国内PNHLB发病年龄较早,以DLBCL最常见.IPI和Ann Arbor分期是PNHLB患者预后的独立影响因素.
목적 분석원발유선비곽기금림파류(PNHLB)적림상특점여예후.방법 회고성분석45례PNHLB적림상특점.5례행유방개량근치술,5례행환측유방단순절제술.43례행CHOP혹CHOP양연합화료,기중6례가용리타석단항.19례화료후행국부방료,1례부행단순방료.45례환자균획수방,수방시간6～180개월.결과 45례PNHLB환자중,미만대B세포성림파류(DLBCL)37례,T세포형림파류4례,점막상관림파조직양림파류(MALT)4례.일선화료적유효솔위90.7%.중위총생존기(OS)위6.82년,중위무진전생존기(PFS)위4.25년.Cox비례풍험모형분석결과현시,IPI(RR=5.682,P=0.002)、Ann Arbor분기(RR=1.836,P=0.040)시PNHLB환자OS적독립영향인소,중추신경계통침윤(RR=1.107,P=0.005)시PFS적독립영향인소.결론 국내PNHLB발병년령교조,이DLBCL최상견.IPI화Ann Arbor분기시PNHLB환자예후적독립영향인소.
Objective To analyze the clinical characteristics and prognosis of primary non-Hodgkin's lymphoma of the breast(PNHLB).Methods The characteristics,treatment methods and outcomes of 45 patients with PNHLB were retrospectively analyzed.Chemotherapy including CHOP and CHOP-like regimens was administered in 43 patients,and monoclonal antibody therapy in 6 patients.Furthermore,19 patients underwent radiotherapy after chemotherapy.Results Of these 45 patients,37 patients had diffuse large B cell lymphoma(DLBCL),patients with T cell or mucosa-associated lymphoid tissue(MALT)lymphoma were 4,respectively.Overall response rate of first-line chemotherapy was 90.7%.Median overall survival(OS)and progression-free survival(PFS)of all patients was 6.82 and 4.25 years,respectively.The resuhs of Cox regression model analysis showed that international prognostic index score(IPI)(RR=5.682,P=0.002)and Ann Arbor stage(RR=1.836,P=0.040)were negative independent prognostic factors for OS.Central nervous system involvement(RR=1.107,P=0.005)was a negative independent prognostic factor for PFS.Conclusion The patients with PNHLB have early occurrence in lifospan.Most pathologic type was DLBCL.IPI and Ann Arbor stage are two independent prognostic factors for survival.