CAJ | 학술논문

目的探讨在汉族人群中生父生育年龄与子女罹患精神分裂症风险的相关性.方法收集351例精神分裂症患者与199名健康志愿者进行病例对照研究.将患者生父母生育年龄分组,以26～30岁组作为参照组,分别对生父母生育年龄的不同组别进行分类变量的Logistic回归分析,并予被试年龄、性别、生母或生父生育年龄等进行校正.结果校正后,与生育年龄在26~30岁的父亲相比,31~35岁、36~40岁、≥41岁3个年龄组父亲子女罹患精神分裂症的OR值分别为3.834、8.805和11.619(P<0.05);父亲生育年龄≤25岁时,子女罹患精神分裂症的OR值为0.877(P>0.05).生母各生育年龄组P值无统计学意义.结论生父生育年龄与子女罹患精神分裂症显著相关;生父生育年龄越大,子女罹患精神分裂症的风险越高.推测这一风险作用的生物学机制是随着男性年龄的增长,生殖细胞的分化成熟过程中会不断积累新发突变或父系基因印迹异常.
목적 탐토재한족인군중생부생육년령여자녀리환정신분렬증풍험적상관성.방법 수집351례정신분렬증환자여199명건강지원자진행병례대조연구.장환자생부모생육년령분조,이26～30세조작위삼조조,분별대생부모생육년령적불동조별진행분류변량적Logistic회귀분석,병여피시년령、성별、생모혹생부생육년령등진행교정.결과 교정후,여생육년령재26~30세적부친상비,31~35세、36~40세、≥41세3개년령조부친자녀리환정신분렬증적OR치분별위3.834、8.805화11.619(P<0.05);부친생육년령≤25세시,자녀리환정신분렬증적OR치위0.877(P>0.05).생모각생육년령조P치무통계학의의.결론 생부생육년령여자녀리환정신분렬증현저상관;생부생육년령월대,자녀리환정신분렬증적풍험월고.추측저일풍험작용적생물학궤제시수착남성년령적증장,생식세포적분화성숙과정중회불단적루신발돌변혹부계기인인적이상.
Objective To investigate whether advanced paternal age is related to an increased risk of schizophrenia in Chinese Han population. Methods A case-control design study was performed. Three hundred and fifty-one patients with schizophrenia and 199 unrelated healthy volunteers were recruited. By using Logistic regression, paternal age was divided into five categories, and maternal age into four categories. Setting the paternal age of 26-30 years as reference, the OR, P values and 95% CI of the other paternal age categories were analyzed, respectively. The participant's sex, age and parental age at birth were used as covariants for adjusting confounding effects. Results The OR for schizophrenia in offspring whose paternal age at birth of 31-35 years, 36-40 years, and ≥41 years categories were 3.834, 8.805, and 11.619 respectively. The advanced maternal age had no significant effects on the risk for schizophrenia in offspring. Conclusion The advanced paternal age was associated with elevated risk for schizophrenia in offspring among a Han Chinese population. Putative biological mechanisms may include accumulated de novo mutations and alterations in epigenetic regulations with aging in spermatogenesis.