中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2010年
1期
92-94
,共3页
王锋%廖予妹%王武亮%黄冬梅
王鋒%廖予妹%王武亮%黃鼕梅
왕봉%료여매%왕무량%황동매
卵巢癌%人附睾分泌蛋白4%CA125
卵巢癌%人附睪分泌蛋白4%CA125
란소암%인부고분비단백4%CA125
Ovarian cancer%Human epididymis protein 4%CA125
目的 探讨血清人附睾分泌蛋白4(HE4)联合CA125检测对卵巢癌的诊断价值.方法 对31例卵巢癌患者、68例盆腔良性包块(包括卵巢良性肿瘤36例、卵巢巧克力样囊肿23例和盆腔脓肿9例)及40名健康妇女的血清样品,采用酶联免疫法(ELISA法)测定HFA含量、电化学发光法测定CA125含量.结果 卵巢癌患者血清HE4水平为(412.3±278.6)pmol/L,盆腔良性包块患者及健康妇女HE4水平分别为(67.7±28.2)、(65.3±21.5)pmoL/L;以上3组CA125水平分别为(398.6±200.5)、(25.5±22.1)、(11.6±7.7)U/ml.卵巢癌患者血清HFA、CA125水平明显高于盆腔良性包块患者及健康妇女,差异均有统计学意义(P均<0.01),而盆腔良性包块患者血清HE4、CA125水平与健康妇女比较,差异均无统计学意义(P均>0.05).HE4检测敏感度、特异度分别为74.2%、95.0%;CA125检测敏感度、特异度分别为80.6%、87.5%;联合检测敏感度、特异度分别为93.5%、82.5%.结论 HE4是一种较理想的卵巢癌肿瘤标志物,其血清水平对卵巢肿瘤的良恶性辅助诊断及鉴别诊断具有一定的应用价值,联合CAl25检测可以提高对卵巢癌的诊断能力.
目的 探討血清人附睪分泌蛋白4(HE4)聯閤CA125檢測對卵巢癌的診斷價值.方法 對31例卵巢癌患者、68例盆腔良性包塊(包括卵巢良性腫瘤36例、卵巢巧剋力樣囊腫23例和盆腔膿腫9例)及40名健康婦女的血清樣品,採用酶聯免疫法(ELISA法)測定HFA含量、電化學髮光法測定CA125含量.結果 卵巢癌患者血清HE4水平為(412.3±278.6)pmol/L,盆腔良性包塊患者及健康婦女HE4水平分彆為(67.7±28.2)、(65.3±21.5)pmoL/L;以上3組CA125水平分彆為(398.6±200.5)、(25.5±22.1)、(11.6±7.7)U/ml.卵巢癌患者血清HFA、CA125水平明顯高于盆腔良性包塊患者及健康婦女,差異均有統計學意義(P均<0.01),而盆腔良性包塊患者血清HE4、CA125水平與健康婦女比較,差異均無統計學意義(P均>0.05).HE4檢測敏感度、特異度分彆為74.2%、95.0%;CA125檢測敏感度、特異度分彆為80.6%、87.5%;聯閤檢測敏感度、特異度分彆為93.5%、82.5%.結論 HE4是一種較理想的卵巢癌腫瘤標誌物,其血清水平對卵巢腫瘤的良噁性輔助診斷及鑒彆診斷具有一定的應用價值,聯閤CAl25檢測可以提高對卵巢癌的診斷能力.
목적 탐토혈청인부고분비단백4(HE4)연합CA125검측대란소암적진단개치.방법 대31례란소암환자、68례분강량성포괴(포괄란소량성종류36례、란소교극력양낭종23례화분강농종9례)급40명건강부녀적혈청양품,채용매련면역법(ELISA법)측정HFA함량、전화학발광법측정CA125함량.결과 란소암환자혈청HE4수평위(412.3±278.6)pmol/L,분강량성포괴환자급건강부녀HE4수평분별위(67.7±28.2)、(65.3±21.5)pmoL/L;이상3조CA125수평분별위(398.6±200.5)、(25.5±22.1)、(11.6±7.7)U/ml.란소암환자혈청HFA、CA125수평명현고우분강량성포괴환자급건강부녀,차이균유통계학의의(P균<0.01),이분강량성포괴환자혈청HE4、CA125수평여건강부녀비교,차이균무통계학의의(P균>0.05).HE4검측민감도、특이도분별위74.2%、95.0%;CA125검측민감도、특이도분별위80.6%、87.5%;연합검측민감도、특이도분별위93.5%、82.5%.결론 HE4시일충교이상적란소암종류표지물,기혈청수평대란소종류적량악성보조진단급감별진단구유일정적응용개치,연합CAl25검측가이제고대란소암적진단능력.
Objective To investigate the significance of haman epididymis protein 4(HE4)as a tumor marker combined with CA125 in diagnosis of epithelial ovarian cancer.Methods Serum levels of HE4 and CA125 were examined by ELISA and electrochemiluminescence method in 31 patients with ovarian cancer,68 patients with benign pelvic masses(36 benign ovarian tumor,23 ovarian chocolate cyst and 9 pelvic abscess were included) and 40 normal women as controls.Results Serum levels of HE4 and CA125 in ovarian carcinoma group were significantly higher than those in the benign pelvic masses group and healthy women group(P<0.01), and the difference of these levels between benign pelvic masses and normal ones have no statistical meaning(P>0.05).The sensitivity and the specificity of HFA were 74.2% and 95.0% respectively,of CA125,were 80.6% and 87.5%.respectively,and if the two markers combined,were 93.5% and 82.5%.Conclusions HFA is an ideal tumor marker and it has certain values in accessory diagnosis and differential diagnosis of ovarian cancer.The clinical value call be improved by combined detection of HE4 and CA125.
