CAJ | 학술논문

氟比洛芬酯是氟比洛芬的药物前体,经过酯化作用而制成.氟比洛芬酯注射液可以选择性聚集在手术切口及炎症部位,抑制环氧化酶,减少前列腺素的生物合成,阻断对内源性炎症介质的伤害性疼痛反应,从而发挥镇痛作用.氟比洛芬酯主要用于术后镇痛,在围术期应用可以减少麻醉性镇痛药物的用量,同时也减少了镇痛药物的副作用.
불비락분지시불비락분적약물전체,경과지화작용이제성.불비락분지주사액가이선택성취집재수술절구급염증부위,억제배양화매,감소전렬선소적생물합성,조단대내원성염증개질적상해성동통반응,종이발휘진통작용.불비락분지주요용우술후진통,재위술기응용가이감소마취성진통약물적용량,동시야감소료진통약물적부작용.
Flurbiprofen axetil is composed by esterification of flurbiprofen. Flurbiprofen axetil injection can selectively aggregate at surgical wound and inflammatory site, inhibit the biosynthesis of prostaglandins by depression of cyclooxygenase, and interrupt endogenous inflammatory factors-mediated injury, therefore exerting its analgesic effect. Flurbiprofen axetil has been successfully used for treatment of postoperative pain, reduce the perioperative requirement of opioid agents and their side-effects.