CAJ | 학술논문

介导先天免疫和炎性反应的Toll样受体(TLR)4参与了炎性反应性疾病的发病.炎性反应在2型糖尿病(T2DM)及其并发症的发生、发展中具有重要作用.TLR4信号通路的激活与胰岛素抵抗(IR)有关,而IR是T2DM及其大血管病变的重要病理生理基础,TLR4信号通路激活后炎性反应因子释放增加,与糖尿病微血管病变及神经病变密切相关.抑制TLR4信号通路的激活可能会防治T2DM及其并发症的发生、发展.
개도선천면역화염성반응적Toll양수체(TLR)4삼여료염성반응성질병적발병.염성반응재2형당뇨병(T2DM)급기병발증적발생、발전중구유중요작용.TLR4신호통로적격활여이도소저항(IR)유관,이IR시T2DM급기대혈관병변적중요병리생리기출,TLR4신호통로격활후염성반응인자석방증가,여당뇨병미혈관병변급신경병변밀절상관.억제TLR4신호통로적격활가능회방치T2DM급기병발증적발생、발전.
Toll-like receptor (TLR) 4,which is related to immunity and inflammation,participates in the progress of inflammatory diseases. Inflammation plays an important role in type 2 diabetes mellitus (T2DM) and its complications. The activation of TLR4 signaling is associated with insulin resistance (IR), and IR is the main characteristic and pathogenesis of T2DM and its macrovascular complications. Enhanced secretion of cytokines after TLR4 activation is closely related to diabetic microangiopathy and neuropathy. Inhibition of TLR4 signaling may prevent the progress of T2DM and its complications.