CAJ | 학술논문

目的评价锌指蛋白804A( ZNF804A)基因rs1344706和rs4667001位点多态性与精神分裂症的关联性,rs1344706位点多态性与抗精神病药物疗效的相关性.方法在Medline、CNKI等中英文数据库中检索,获取关于ZNF804A基因多态性与精神分裂症及其药物疗效的文献,筛选文献并对纳入文献进行质量评分和数据提取,使用RevMan 5.1软件进行Meta分析.结果 rs1344706的T等位基因频率在精神分裂症组中高于对照组[OR =1.13,95％CI(1.06 ～ 1.21),P=0.0003]；rs4667001的G等位基因频率在精神分裂症组中高于对照组[OR=1.14,95％CI(1.04 ～ 1.26),P=0.005]；rs1344706的不同等位基因携带者的第四周PANSS量表减分率差异无统计学意义.结论 ZNF804A基因的rs1344706 T等位基因和rs4667001 G等位基因与精神分裂症易感性相关,rs1344706位点多态性与抗精神分裂症药物疗效无关.
목적 평개자지단백804A( ZNF804A)기인rs1344706화rs4667001위점다태성여정신분렬증적관련성,rs1344706위점다태성여항정신병약물료효적상관성.방법 재Medline、CNKI등중영문수거고중검색,획취관우ZNF804A기인다태성여정신분렬증급기약물료효적문헌,사선문헌병대납입문헌진행질량평분화수거제취,사용RevMan 5.1연건진행Meta분석.결과 rs1344706적T등위기인빈솔재정신분렬증조중고우대조조[OR =1.13,95％CI(1.06 ～ 1.21),P=0.0003]；rs4667001적G등위기인빈솔재정신분렬증조중고우대조조[OR=1.14,95％CI(1.04 ～ 1.26),P=0.005]；rs1344706적불동등위기인휴대자적제사주PANSS량표감분솔차이무통계학의의.결론 ZNF804A기인적rs1344706 T등위기인화rs4667001 G등위기인여정신분렬증역감성상관,rs1344706위점다태성여항정신분렬증약물료효무관.
Objective To assess the association of rs1344706 and rs4667001 polymorphism of ZNF804A gene with schizophrenia,and the relationship between rs1344706 polymorphism and antipsychotic drug efficacy.Methods The studies concerning association of ZNF804A gene polymorphism with schizophrenia and its drug efficacy were retrieved in databases such as Medline and CNKI,and then screened according to the inclusion and exclusion criteria.Meta-analysis was performed by RevMan 5.1 following quality assessment and data extraction.Results Eleven high-quality studies under the criteria were included.For rs1344706,T allele frequency was significant higher in the schizophrenia group than control group ( OR=1.13,95％ CI (1.06-1.21 ),P=0.0003).Moreover,for rs4667001,G allele frequency was significant higher in the schizophrenia group ( OR =1.14,95％ CI( 1.04-1.26),P =0.005 ).In addition,the difference of PANSS scores reduction between T allele and GG genotype carriers was not significant in both positive and negative symptoms after four-week treatment,and the same trend of difference was in the comparison between TT genotype and G allele carriers.Conclusion The data supports that T allele of rs1344706 and G allele of rs4667001 in ZNF804A gene are associated with the susceptibility of schizophrenia,but rs1344706 polymorphism is not related to antipsychotic drug efficacy.