CAJ | 학술논문

目的评价普拉洛芬联合人工泪液治疗急性结膜炎后干眼症的临床疗效.方法收集本院眼科2008年7月至2010年9月就诊的急性结膜炎经常规治疗痊愈后确诊为干眼症(排除其他病因引发干眼症的因素及有干眼病史)的患者157例206眼,随机分为人工泪液组(79例104眼)和联合组(78例102眼),人工泪液组采用单纯人工泪液治疗,联合组在使用人工泪液基础上加用普拉洛芬滴眼液治疗.观察用药3、7、14 d后两组患者自觉症状缓解情况及客观指标(泪液分泌试验SIT、角膜荧光素染色FL、泪膜破裂时间BUT)的改善情况.结果所有患者均按要求完成治疗和随访.两组患者药物治疗后自觉症状均有不同程度的改善,联合组改善尤为明显,起效时间也较快,且SIT、FL、BUT较人工泪液组相比,差异有统计学意义(P＜0.05,P＜0.01).结论普拉洛芬联合人工泪液治疗急性结膜炎后干眼症疗效明显优于单纯人工泪液治疗.
목적 평개보랍락분연합인공루액치료급성결막염후간안증적림상료효.방법 수집본원안과2008년7월지2010년9월취진적급성결막염경상규치료전유후학진위간안증(배제기타병인인발간안증적인소급유간안병사)적환자157례206안,수궤분위인공루액조(79례104안)화연합조(78례102안),인공루액조채용단순인공루액치료,연합조재사용인공루액기출상가용보랍락분적안액치료.관찰용약3、7、14 d후량조환자자각증상완해정황급객관지표(루액분비시험SIT、각막형광소염색FL、루막파렬시간BUT)적개선정황.결과 소유환자균안요구완성치료화수방.량조환자약물치료후자각증상균유불동정도적개선,연합조개선우위명현,기효시간야교쾌,차SIT、FL、BUT교인공루액조상비,차이유통계학의의(P＜0.05,P＜0.01).결론 보랍락분연합인공루액치료급성결막염후간안증료효명현우우단순인공루액치료.
Objective To observe the efficacy of combination of pranoprofen and artificial tears in treatment of dry eye syndrome after recovery from acute conjunctivitis. Methods This study involved 206 eyes of 157 consecutive patients who had recovered from acute conjunctivitis after routine treatment between July 2008 and September 2010. All cases were randomly divided into artificial tears group (79cases,104eyes) : artificial tears eye drops alone and combination group(78cases,102eyes) : pranoprofen combined with application of artificial tears eye drops. All patients'symptoms, signs such as tear film break 2 up time (BUT ) ,Schirmer I test (SIT) , corneal fluoresce staining (FL) score at 3,7,14days after treatment Were observed. Results All patients finished the trial at the end of the follow-up duration. There were significant differences in symptoms, BUT and corneal fluoresce staining between the two groups after treatment,combination group was superior to artificial tears group in BUT and FL. Conclusion Pranoprofen combined with artificial tears eye drops is superior to artificial tears eye drops alone