CAJ | 학술논문

目的探讨影响脑胶质瘤患者术后生存的因素.方法分析2000-2006年在山东大学齐鲁医院行手术治疗的522例脑胶质瘤患者的临床资料,随访12～72个月,选择可能影响预后的因素进行生存分析.分析方法采用Kaplan-Meier法(K-M法)、对数秩检验(Log-rank法)及Cox比例风险回归模型.结果对数秩检验分析结果显示在α=0.05水平上,年龄、性别、手术切除程度、病理级别因素与患者的生存率有关;单因素Cox回归分析上述4个因素也均有统计学意义(P<0.05),HR值分别为0.811、1.553、1.634和1.429;多因素Cox模型显示年龄、病理分级、手术切除程度是影响患者生存的主要因素,随着肿瘤病理诊断分级恶性程度的增加HR值增加(Ⅱ、Ⅲ、Ⅳ级HR值分别为2.349、3.826、5.062),只有手术大部切除进入模型,HR值为1.459;其余因素对生存率的影响无统计学意义.结论患病年龄、手术切除程度、病理分级及术后放疗、化疗均可能影响患者的预后.
목적 탐토영향뇌효질류환자술후생존적인소.방법 분석2000-2006년재산동대학제로의원행수술치료적522례뇌효질류환자적림상자료,수방12～72개월,선택가능영향예후적인소진행생존분석.분석방법채용Kaplan-Meier법(K-M법)、대수질검험(Log-rank법)급Cox비례풍험회귀모형.결과 대수질검험분석결과현시재α=0.05수평상,년령、성별、수술절제정도、병리급별인소여환자적생존솔유관;단인소Cox회귀분석상술4개인소야균유통계학의의(P<0.05),HR치분별위0.811、1.553、1.634화1.429;다인소Cox모형현시년령、병리분급、수술절제정도시영향환자생존적주요인소,수착종류병리진단분급악성정도적증가HR치증가(Ⅱ、Ⅲ、Ⅳ급HR치분별위2.349、3.826、5.062),지유수술대부절제진입모형,HR치위1.459;기여인소대생존솔적영향무통계학의의.결론 환병년령、수술절제정도、병리분급급술후방료、화료균가능영향환자적예후.
Objective To analyze the risk factors that associated with survival of postoperative patients with glioma. Methods From 2000 to 2006, 522 patients were enrolled in our hospital and were analyzed related risk factors by using Kaplan-Meier' s Product-Limit Survival Estimates method, log-rank test and Cox' s proportional-hazards model. Analysis of data were performed in SAS 9.1. Results In univariate analysis, age, sex, extent of resection in surgery and pathological grades appeared to be associated with survival rate of the patients (α=0.05). Cox regression analysis showed these four factors were also significant (HR value 0.811, 1.553, 1.634 and 1.429, respectively). Multivariate Cox regression model also showed that age, pathological grades and extent of resection in surgery were main factors affecting the survival of the patients while HR value increased with the ascending class (2.349, 3.826, and 5.062, respectively)with only subtotal excision enter the model (HR=1.459). Other factors had no statistical importance on survival rate. Conclusion Age, extent of resection in surgery, pathological grades, chemotherapy after surgery, and radiotherapy after surgery might associate with the prognosis of the patients with glioma.