CAJ | 학술논문

目的观察替吉奥胶囊治疗老年晚期胃癌的疗效及不良反应.方法 42例具有可测量指标的老年晚期胃癌患者给予替吉奥胶囊80 mg/m2,分2次口服,连服28d,休息14 d为1个周期,连用2个周期,按RECIST 1.1标准评价客观疗效和不良反应.结果 42例患者中完全缓解(CR)1例,部分缓解(PR) 18例,病情稳定(SD)11例和病情进展(PD)12例,总有效率(RR)为45.2％( 19/42),疾病控制率(DCR)为71.4％ (30/42).主要不良反应为白细胞减少、全身倦怠感、恶心、呕吐等.结论替吉奥胶囊治疗进展期胃癌有较好疗效,不良反应小,特别适宜于年老体弱患者.
목적 관찰체길오효낭치료노년만기위암적료효급불량반응.방법 42례구유가측량지표적노년만기위암환자급여체길오효낭80 mg/m2,분2차구복,련복28d,휴식14 d위1개주기,련용2개주기,안RECIST 1.1표준평개객관료효화불량반응.결과 42례환자중완전완해(CR)1례,부분완해(PR) 18례,병정은정(SD)11례화병정진전(PD)12례,총유효솔(RR)위45.2％( 19/42),질병공제솔(DCR)위71.4％ (30/42).주요불량반응위백세포감소、전신권태감、악심、구토등.결론 체길오효낭치료진전기위암유교호료효,불량반응소,특별괄의우년로체약환자.
Objective To observe the efficacy and adverse reactions of S-1 capsule in the treatment of elderly patients with advanced gastric cancer.Methods Forty-two patients with advanced gastric cancer were enrolled.S-1 was administered orally twice daily after meals,at a standard dose of 80 mg/m2.One course consisted of consecutive administratiorn for 28 days and 14 days' rest.Administration was repeated 2 courses at least.Efficacy and adverse reactions were evaluated according to the RECIST 1.1 standard.Results Among the 42 patients,the complete response was achieved in 1 patient,partial response in 18 patients,stable disease in 11 patients and progressive disease in 12 patients.The total response rate was 45.2％ (19/42).The disease controll rate was 71.4％ (30/42).The major adverse reactions were leucopenia,malaise,nausea and emesis.No serious unexpected adverse reactions were observed.Conclusions S-1 capsule is effective and tolerable in the treatment of patients with advanced gastric cancer,especially for elderly patients.