中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2010年
21期
2899-2900
,共2页
冠状动脉疾病%心绞痛%普罗布考%阿托伐他汀
冠狀動脈疾病%心絞痛%普囉佈攷%阿託伐他汀
관상동맥질병%심교통%보라포고%아탁벌타정
Coronary disease%Angina pectoris%Probucol%Atorvastatin
目的 观察普罗布考联合阿托伐他汀治疗不稳定型心绞痛的临床疗效及安全性.方法 100例不稳定型心绞痛患者按随机原则分为A组和B组各50组,在常规治疗的基础上,A组采用普罗布考治疗,B组采用普罗布考联合阿托伐他汀治疗,观察两组治疗前后疗效、平板运动心电图试验、血脂及氧化指标变化情况.结果 B组总有效率90.0%,明显高于A组64.0%(χ2=3.841,P＜0.05);B组治疗后心电图改善总有效率为74.0%,明显高于A组42.0%(χ2=3.981,P＜0.05);两组治疗后平板运动心电图试验阳性率明显低于治疗前(χ2=3.841、3.791,均P＜0.05);A、B组治疗后心绞痛发作[(1.6±0.8)次、(1.0±0.5)次]明显低于治疗前[(4.3±1.9)次、(4.6±2.8)次](χ2=7.584、7.984,均P＜0.01).结论 普罗布考联合阿托伐他汀治疗不稳定型心绞痛可明显减少心绞痛发作、改善患者临床症状.
目的 觀察普囉佈攷聯閤阿託伐他汀治療不穩定型心絞痛的臨床療效及安全性.方法 100例不穩定型心絞痛患者按隨機原則分為A組和B組各50組,在常規治療的基礎上,A組採用普囉佈攷治療,B組採用普囉佈攷聯閤阿託伐他汀治療,觀察兩組治療前後療效、平闆運動心電圖試驗、血脂及氧化指標變化情況.結果 B組總有效率90.0%,明顯高于A組64.0%(χ2=3.841,P＜0.05);B組治療後心電圖改善總有效率為74.0%,明顯高于A組42.0%(χ2=3.981,P＜0.05);兩組治療後平闆運動心電圖試驗暘性率明顯低于治療前(χ2=3.841、3.791,均P＜0.05);A、B組治療後心絞痛髮作[(1.6±0.8)次、(1.0±0.5)次]明顯低于治療前[(4.3±1.9)次、(4.6±2.8)次](χ2=7.584、7.984,均P＜0.01).結論 普囉佈攷聯閤阿託伐他汀治療不穩定型心絞痛可明顯減少心絞痛髮作、改善患者臨床癥狀.
목적 관찰보라포고연합아탁벌타정치료불은정형심교통적림상료효급안전성.방법 100례불은정형심교통환자안수궤원칙분위A조화B조각50조,재상규치료적기출상,A조채용보라포고치료,B조채용보라포고연합아탁벌타정치료,관찰량조치료전후료효、평판운동심전도시험、혈지급양화지표변화정황.결과 B조총유효솔90.0%,명현고우A조64.0%(χ2=3.841,P＜0.05);B조치료후심전도개선총유효솔위74.0%,명현고우A조42.0%(χ2=3.981,P＜0.05);량조치료후평판운동심전도시험양성솔명현저우치료전(χ2=3.841、3.791,균P＜0.05);A、B조치료후심교통발작[(1.6±0.8)차、(1.0±0.5)차]명현저우치료전[(4.3±1.9)차、(4.6±2.8)차](χ2=7.584、7.984,균P＜0.01).결론 보라포고연합아탁벌타정치료불은정형심교통가명현감소심교통발작、개선환자림상증상.
Objective To compare the influence of blood lipids and angina pectoris using combination therapy in coronary heart diseases(CHD) with unstable angina.Methods 100 patients were randomly divided into the probucol group(A group) 50 cases and probucol combined with atorvastatin treatment group(B group) 50 cases,The treadmill exercise ECG test,lipid and oxidation before and after treatment in two groups were observed.Results The total effective rate was 90.0% in group B significantly higher than 64.0% in group A(χ2 =3.841,P＜0.05);The total effective rate of ECG was 74.0% in group B after treatment which was significantly higher than the 42.0% in group A(χ2 = 3.981,P＜0.05);Treadmill exercise ECG test positive 82.0%,84.0% in two group before treatment,significantly higher than that 48.0%,24.0% in two group after treatment,(χ2 = 3.841,3.791,all P＜0.05);Angina pectoris in A、 B group after treatment [(1.6 ± 0.8) times、(1.0 ± 0.5) times]were significantly lower than [(4.3±1.9) times、(4.6 ±2.8) times]before treatment(χ2 =7.584,7.984,all P＜0.01).Conclusion Probucol was a safe and effective drug for treating hypolipidemic and reducing angina attack.Its combination with atorvastatin was safe,and the efficacy is more visible.
