CAJ | 학술논문

目的比较和探讨3种氟喹诺酮类药物(氧氟沙星、左氧氟沙星、莫西沙星)治疗耐药肺结核(MDR-TB)的经济效果和最佳治疗方案.方法将经痰培养检查证实的108例耐药肺结核患者完全随机分为3组,各36例,同期进行临床研究,3组除均给予一定量的利福喷丁、吡嗪酰胺、对氨基水杨酸异烟肼、丙硫异烟胺、链霉素外,在抗痨方案上分别加入氧氟沙星、左氧氟沙星、莫西沙星,再运用药物经济学的成本-效果分析方法进行评价.结果治疗15个月后,在痰菌转阴率、X线病灶吸收率比较中,左氧氟沙星与莫西沙星效果相近,优于氧氟沙星;不良反应发生等指标各组间比较无统计学意义(P＞0.05).各组间的医疗费用差异有统计学意义(P＜0.05).结论左氧氟沙星是治疗耐药肺结核的最佳治疗方案.
목적 비교화탐토3충불규낙동류약물(양불사성、좌양불사성、막서사성)치료내약폐결핵(MDR-TB)적경제효과화최가치료방안.방법 장경담배양검사증실적108례내약폐결핵환자완전수궤분위3조,각36례,동기진행림상연구,3조제균급여일정량적리복분정、필진선알、대안기수양산이연정、병류이연알、련매소외,재항로방안상분별가입양불사성、좌양불사성、막서사성,재운용약물경제학적성본-효과분석방법진행평개.결과 치료15개월후,재담균전음솔、X선병조흡수솔비교중,좌양불사성여막서사성효과상근,우우양불사성;불량반응발생등지표각조간비교무통계학의의(P＞0.05).각조간적의료비용차이유통계학의의(P＜0.05).결론 좌양불사성시치료내약폐결핵적최가치료방안.
Objective To discuss and compare the economic effect and the optimal treatment regimen of 3 kinds of fluoroquinolone drug including ofloxacin,levofloxacin,moxifloxacin in treatment of drug resistant tuberculosis (MDR-TB).Methods All 108 cases of MDR-TB confirmed by speutum examination were randomly divided into 3 groups,The patients in three groups were given a certain amount of rifapentine isoniazid,pyrazinamide,salicylic acid,propylene ethionamide,streptomycin,during anti-tuberculosis scheme,oxygen fluorine ofloxacin,levofloxacin,moxifloxacin added,respectively.Cost-effectiveness analysis method was taken,and the cost and effectiveness were evaluated.Results After 15 months of treatment,in the sputum negative conversion rate,radiologic lesions absorption rates,levofloxacin and moxifloxacin had similar effects,and were superior to that of ofloxacin; adverse reaction and other indicators among three groups had no significant statistical difference.There was a statistically significant difference in the medical expenses among three groups.Conclusion Levofloxacin in treatment of drug resistant tuberculosis is the best therapeutic scheme.