CAJ | 학술논문

目的探讨血浆同型半胱氨酸与糖尿病视网膜病变(DR)的关系.方法比较40例DR(DR组)和63例非DR(非DR组)2型糖尿病患者血浆同型半胱氨酸水平、病程、年龄、血压、空腹血糖、糖化血红蛋白(GHbA1c)、血脂、叶酸及维生素B12等与DR可能相关的指标.结果 DR组血浆同型半胱氨酸水平中位数为12.9μmol/L,与非DR组的7.8μmol/L比较,差异有统计学意义(P＜0.01),两组在校正了病程、GHbA1c、年龄、叶酸及维生素B12后仍显著相关(DR值1.23,P＜0.05).结论高同型半胱氨酸血症为DR的危险因素,并为独立的预测因子.
목적 탐토혈장동형반광안산여당뇨병시망막병변(DR)적관계.방법 비교40례DR(DR조)화63례비DR(비DR조)2형당뇨병환자혈장동형반광안산수평、병정、년령、혈압、공복혈당、당화혈홍단백(GHbA1c)、혈지、협산급유생소B12등여DR가능상관적지표.결과 DR조혈장동형반광안산수평중위수위12.9μmol/L,여비DR조적7.8μmol/L비교,차이유통계학의의(P＜0.01),량조재교정료병정、GHbA1c、년령、협산급유생소B12후잉현저상관(DR치1.23,P＜0.05).결론 고동형반광안산혈증위DR적위험인소,병위독립적예측인자.
Objective To explore the relationship between plasma homocysteine levels and diabetic retinopathy (DR).MethodIn 40 DR patients and 63 non-DR patients,the indexes including plasma homocysteine concentrations,duration of diabetes,ages,blood pressure,preprandial blood glucose(PBG),plasma GHbA,e,plasma lipids,serum folie acid and semm vitamin B12 were analyzed.ResultsPlasma homocysteine level was significantly higher in DR patients (12.9μmol/L) than that in non-DR patients (7.8μ.mol/L) (P＜0.01),and the relationship remained significant correlation after adjusted for duration of diabetes,GHbA1c,ages,serum folic acid and serum vitamin B12(OR = 1.23,P＜0.05).ConclusionHyperhomocysteinimia is a risk factor and an independent predieator of DR.