CAJ | 학술논문

目的分析和比较非变应性鼻炎(non-allergic rhinitis,NAR)与变应性鼻炎(allergic rhinitis,AR)的临床特征以及伴随疾病.方法以2010年1月至2011年6月期间,主诉鼻塞、流涕、喷嚏和鼻痒症状中至少有2个症状的门诊患者556例作为研究对象,根据病史、体征和变应原检测结果进行诊断,其中NAR患者206例、AR患者350例.通过调查问卷详细记录患者一般信息、鼻部症状、伴发症状和各种合并症等,采用记分法评价症状严重程度.以SPSS13.0软件对数据进行统计学分析.结果 NAR患者的平均(x±s,下同)年龄(31.8±16.7)岁,高于AR患者的(26.3±14.8)岁,差异有统计学意义(t=4.01,P=0.0001)；而性别构成比的差异无统计学意义(x2=0.12,P=0.73).在各种临床表现中,NAR和AR患者鼻塞症状出现率(分别为89.8％和92.0％)的差异无统计学意义(x2 =0.26,P=0.611),但AR患者的流涕、喷嚏、鼻痒、眼痒、流泪、喘息和咳嗽症状出现率均明显高于NAR患者,差异均有统计学意义(P值均＜0.05).而且这些症状(咳嗽除外)在AR患者中尤为严重,其症状评分明显高于NAR患者,差异均有统计学意义(P值均＜0.05).NAR和AR患者中大多数为中-重度持续性,分别占67.0％和62.9％,差异无统计学意义(x2=1.25,P =0.264).AR患者合并支气管哮喘明显多于NAR患者(分别为12.6％和2.4％),NAR患者合并高血压明显多于AR患者(分别为7.3％和1.7％),差异均有统计学意义(P值均＜0.05).结论 NAR和AR是两类具有不同临床特征的疾病,两者的合并症也存在某些差异,故值得进一步加强对鼻炎表型的临床研究.
목적 분석화비교비변응성비염(non-allergic rhinitis,NAR)여변응성비염(allergic rhinitis,AR)적림상특정이급반수질병.방법 이2010년1월지2011년6월기간,주소비새、류체、분체화비양증상중지소유2개증상적문진환자556례작위연구대상,근거병사、체정화변응원검측결과진행진단,기중NAR환자206례、AR환자350례.통과조사문권상세기록환자일반신식、비부증상、반발증상화각충합병증등,채용기분법평개증상엄중정도.이SPSS13.0연건대수거진행통계학분석.결과 NAR환자적평균(x±s,하동)년령(31.8±16.7)세,고우AR환자적(26.3±14.8)세,차이유통계학의의(t=4.01,P=0.0001)；이성별구성비적차이무통계학의의(x2=0.12,P=0.73).재각충림상표현중,NAR화AR환자비새증상출현솔(분별위89.8％화92.0％)적차이무통계학의의(x2 =0.26,P=0.611),단AR환자적류체、분체、비양、안양、류루、천식화해수증상출현솔균명현고우NAR환자,차이균유통계학의의(P치균＜0.05).이차저사증상(해수제외)재AR환자중우위엄중,기증상평분명현고우NAR환자,차이균유통계학의의(P치균＜0.05).NAR화AR환자중대다수위중-중도지속성,분별점67.0％화62.9％,차이무통계학의의(x2=1.25,P =0.264).AR환자합병지기관효천명현다우NAR환자(분별위12.6％화2.4％),NAR환자합병고혈압명현다우AR환자(분별위7.3％화1.7％),차이균유통계학의의(P치균＜0.05).결론 NAR화AR시량류구유불동림상특정적질병,량자적합병증야존재모사차이,고치득진일보가강대비염표형적림상연구.
Objective To analyze and compare the differences of clinical characteristics and comorbidities between patients with non-allergic rhinitis (NAR) and allergic rhinitis (AR).Methods A total of 556 out-patients were enrolled from January 2010 to June 2011.The chief complaints of the patients included at least two of the following nasal symptoms:nasal congestion,rhinorrhea,sneezing,and nasal itching.Based on the results of the disease history,physical examination and allergen skin prick test,the patients were classified into NAR group (n =206) and AR group (n =350).Detailed information including general data,nasal symptoms and signs,accompanied symptoms and comorbidities were obtained by questionnaires.A scoring was adopted to estimate the severity of disease.SPSS 13.0 software was applied for statistical analysis.Results The mean age of NAR patients ( 31.8 ± 16.7 ) was older than that of AR patients (26.3 ± 14.8),and the difference was significant (t =4.01,P =0.0001 ).While there was no significant difference on gender distribution between two groups (x2 =0.12,P =0.73 ).The percentage of nasal congestion was not significantly different between NAR and AR patients (89.8％ and 92.0％,respectively; x2 =0.26,P =0.611 ).However,the symptoms of rhinorrhea,sneezing,nasal itching,eyes itching,lachrymation,wheeze and cough were more popular in AR patients than those in NAR patients (all P ＜ 0.05 ).Moreover,above symptoms ( except cough) were more serious in AR patients,and the symptom scores were significantly higher than those in NAR patients ( all P ＜ 0.05 ).Most of patients with NAR (67.0％) and AR ( 62.9％ ) were moderate-severe persistent ( x2 =1.25,P =0.264 ).Accompanied asthma were more common in patients with AR ( 12.6％ ) compared with NAR (2.4％ ),while hypertension were more common in patients with NAR (7.3％) compared with AR ( 1.7％ ),and the differences were significant ( both P ＜ 0.05 ).Conclusion NAR and AR are two different disease entities,which have different clinical characteristics,as well as different comorbidities.Further clinical study should be done on the rhinitis phenotypes.