CAJ | 학술논문

目的观察布托非诺对硬膜外腔阻滞后寒战的治疗效果及不良反应.方法将在硬膜外腔阻滞下行腹部手术的病人ASA Ⅰ～Ⅱ级100例随机分为两组,每组50例,布托非诺组(B组)经静脉注射0.04%布托非诺20μg/kg;哌替啶组(P组)经静脉注射1%哌替啶0.75 mg/kg.两组注药部位均为上肢静脉,注药速度均为30 ml/min,若注药5 min后寒战仍未消失者再经静脉加注咪达唑仑0.05 mg/kg.观察两组病人的治疗效果和不良反应.结果两组病人一般情况(性别、年龄、身体指数)、手术部位、静脉给药部位及手术开始前输液速度差异均无统计学意义(P＞0.05),两组注药前寒战的分级与注药后1、5 min治疗效果的判定差异均无统计学意义(P＞0.05),但注药后3min治疗效果的判定B组优于P组(P＜0.05),而B组不良反应明显低于P组(P＜0.01).结论布托非诺治疗硬膜外腔阻滞后寒战效果确切,不良反应少,优于哌替啶,是一种理想的治疗硬膜外阻滞后并发症寒战的药物.
목적 관찰포탁비낙대경막외강조체후한전적치료효과급불량반응.방법 장재경막외강조체하행복부수술적병인ASA Ⅰ～Ⅱ급100례수궤분위량조,매조50례,포탁비낙조(B조)경정맥주사0.04%포탁비낙20μg/kg;고체정조(P조)경정맥주사1%고체정0.75 mg/kg.량조주약부위균위상지정맥,주약속도균위30 ml/min,약주약5 min후한전잉미소실자재경정맥가주미체서륜0.05 mg/kg.관찰량조병인적치료효과화불량반응.결과 량조병인일반정황(성별、년령、신체지수)、수술부위、정맥급약부위급수술개시전수액속도차이균무통계학의의(P＞0.05),량조주약전한전적분급여주약후1、5 min치료효과적판정차이균무통계학의의(P＞0.05),단주약후3min치료효과적판정B조우우P조(P＜0.05),이B조불량반응명현저우P조(P＜0.01).결론 포탁비낙치료경막외강조체후한전효과학절,불량반응소,우우고체정,시일충이상적치료경막외조체후병발증한전적약물.
Objective To observe the clilnical effect of treatment of chill by butorphanol after epidural anesthesthia. Methods One hundred patients under going epidural anesthesia , divided into two groups randomly, 50 in butorphanol group(B)were injected intravenously through upper limbs with 0. 04% butorphanol (diluted with normal saline)20 μg/kg; 50 in pethidine group(P) were injected intravenously through upper limbs with 1% pethidine ( diluted with normal saline )0. 75 mg/kg. The speed of the two injection was30 ml/min, after five minutes the patients who were still chilling were injected with midazolam 0. 05 mg/kg. Observe the effect and complications after one minute, three minutes and five minutes. Results After one minute and five minutes the effect of treating chill was no statistically difference ( P ＞ 0. 05 ).However, after three minutes the effect of the butorphanol group was obviously superior to the pethidine group ( P ＜0. 05) ,And the complications of butorphanol group was also less than pethidine group ( P ＜0. 01) . Conclusion Butorphanol display good effect on treating the chill after epidural anesthesia.