中华神经科杂志
中華神經科雜誌
중화신경과잡지
Chinese Journal of Neurology
2008年
12期
835-839
,共5页
郭峰%张振馨%许群%张俊武%赵华路
郭峰%張振馨%許群%張俊武%趙華路
곽봉%장진형%허군%장준무%조화로
阿尔茨海默病%胎儿发育%载脂蛋白E类%等位基因%人体质量指数
阿爾茨海默病%胎兒髮育%載脂蛋白E類%等位基因%人體質量指數
아이자해묵병%태인발육%재지단백E류%등위기인%인체질량지수
Alzheimer disease%Fetal development%Apolipoprotein E%Alleles%Body mass index
目的 研究载脂蛋白E(ApoE)ε4和ε2等位基因与胎儿宫内发育的关系.方法 以聚合酶链反应.限制性片段长度多态性分析(PCR-RFLP)方法 检测1418名北京协和医院出生人群的ApoE基因型,计算等位基因频率,收集其出生时的相关指标.通过单因素分析和多因素Logistic回归分析比较ApoE ε4和ε2等位基因与新生儿发育状态的关系.结果 本研究人群中ApoE ε2、ε3和ε4 等位基因频率分别为8.11%、83.39%和8.50%.单因素分析结果 表明,携带ε2等位基因者的出生体质量指数(ponderal index,PI)构成差异有统计学意义(χ2=4.87,P=0.027),其头围、胎盘质量和孕周构成差异没有统计学意义.多因素分析结果 表明,调整了性别、年龄、出生头围、胎盘质量、孕周、产次和产妇年龄等因素,携带ApoE ε2等位基因与小PI呈负相关(χ2=5.077,P=0.024).没有发现携带ApoE ε4等位基因与新生儿发育状态存在关联性.结论 ApoE ε2等位基因对PI有保护作用,没有发现ApoE ε4等位基因与胎儿宫内发育有关.
目的 研究載脂蛋白E(ApoE)ε4和ε2等位基因與胎兒宮內髮育的關繫.方法 以聚閤酶鏈反應.限製性片段長度多態性分析(PCR-RFLP)方法 檢測1418名北京協和醫院齣生人群的ApoE基因型,計算等位基因頻率,收集其齣生時的相關指標.通過單因素分析和多因素Logistic迴歸分析比較ApoE ε4和ε2等位基因與新生兒髮育狀態的關繫.結果 本研究人群中ApoE ε2、ε3和ε4 等位基因頻率分彆為8.11%、83.39%和8.50%.單因素分析結果 錶明,攜帶ε2等位基因者的齣生體質量指數(ponderal index,PI)構成差異有統計學意義(χ2=4.87,P=0.027),其頭圍、胎盤質量和孕週構成差異沒有統計學意義.多因素分析結果 錶明,調整瞭性彆、年齡、齣生頭圍、胎盤質量、孕週、產次和產婦年齡等因素,攜帶ApoE ε2等位基因與小PI呈負相關(χ2=5.077,P=0.024).沒有髮現攜帶ApoE ε4等位基因與新生兒髮育狀態存在關聯性.結論 ApoE ε2等位基因對PI有保護作用,沒有髮現ApoE ε4等位基因與胎兒宮內髮育有關.
목적 연구재지단백E(ApoE)ε4화ε2등위기인여태인궁내발육적관계.방법 이취합매련반응.한제성편단장도다태성분석(PCR-RFLP)방법 검측1418명북경협화의원출생인군적ApoE기인형,계산등위기인빈솔,수집기출생시적상관지표.통과단인소분석화다인소Logistic회귀분석비교ApoE ε4화ε2등위기인여신생인발육상태적관계.결과 본연구인군중ApoE ε2、ε3화ε4 등위기인빈솔분별위8.11%、83.39%화8.50%.단인소분석결과 표명,휴대ε2등위기인자적출생체질량지수(ponderal index,PI)구성차이유통계학의의(χ2=4.87,P=0.027),기두위、태반질량화잉주구성차이몰유통계학의의.다인소분석결과 표명,조정료성별、년령、출생두위、태반질량、잉주、산차화산부년령등인소,휴대ApoE ε2등위기인여소PI정부상관(χ2=5.077,P=0.024).몰유발현휴대ApoE ε4등위기인여신생인발육상태존재관련성.결론 ApoE ε2등위기인대PI유보호작용,몰유발현ApoE ε4등위기인여태인궁내발육유관.
Objective To investigate the relationship between apolipoprotein E (ApoE) ε4,ε2 alleles and intrauterine growth.Methods ApoE genotypes of 1418 people born in Peking Union Medical College Hospital were analyzed,allele frequencies were calculated and their parameters at birth were collected.To compare ApoE ε4,ε2 alleles with parameters at birth through single factor analysis and Logistic regression analysis.Results The alleLic frequencies of e2,83 and 84 were 8.11%,83.39% and 8.50% in the group.The results of single factor analysis showed that there was significant difference between the distribution of ponderal index (PI) in the ApoE ε2 allele group(χ2=4.87 ,P=0.027).While there was no significant difference between the distribution of head circumference at birth,placental weight and gestational age in the ApoE ε2 allele group.ApoE ε2 allele showed negative correlation with small PI in the logistic regression analysis(χ2=5.077 ,P=0.024),after adjusted for gender,age,head circumference at birth,placental weight,gestational age,parity and maternal age at delivery.No association between ApoE ε4 allele and parameters at birth was found.Conclusions ApoE ε2 allele may have protective effect on PI.No association was found between ApoE ε4 allele and intrauterine growth.
