CAJ | 학술논문

目的分析乳腺浸润性小叶癌的临床特征及预后情况.方法回顾性分析1990年1月至2008年12月中山大学肿瘤防治中心收治的125例乳腺浸润性小叶癌患者的临床资料,总结其临床特征、复发及生存情况.结果 125例浸润性小叶癌患者的中位年龄45岁(27～76岁),诊断时肿块超过3 cm者占61.6%(77/125),51.2%(64/125)患者区域淋巴结阳性,80.8%(101/125)患者为Ⅱ期以上,89.6%(112/125)患者的激素受体阳性.中位随访58个月(11～222个月),此时有32例出现复发及转移,18例死亡.生存分析显示,浸润性小叶癌患者的5年无病牛存率和总生存率分别为82.2%和87_3%.多因素分析显示,是否进行内分泌治疗是影响浸润性小叶癌的唯一预后因素.结论乳腺浸润性小叶癌患者在发病中位年龄上与其他病理类型乳腺癌无明显差异,诊断时呈现肿瘤较大和淋巴结侵犯较多是该病的一个特点,激素受体阳性率高是该病的另一个特点.临床病理特征的差异没有显著影响患者预后.
목적 분석유선침윤성소협암적림상특정급예후정황.방법 회고성분석1990년1월지2008년12월중산대학종류방치중심수치적125례유선침윤성소협암환자적림상자료,총결기림상특정、복발급생존정황.결과 125례침윤성소협암환자적중위년령45세(27～76세),진단시종괴초과3 cm자점61.6%(77/125),51.2%(64/125)환자구역림파결양성,80.8%(101/125)환자위Ⅱ기이상,89.6%(112/125)환자적격소수체양성.중위수방58개월(11～222개월),차시유32례출현복발급전이,18례사망.생존분석현시,침윤성소협암환자적5년무병우존솔화총생존솔분별위82.2%화87_3%.다인소분석현시,시부진행내분비치료시영향침윤성소협암적유일예후인소.결론 유선침윤성소협암환자재발병중위년령상여기타병리류형유선암무명현차이,진단시정현종류교대화림파결침범교다시해병적일개특점,격소수체양성솔고시해병적령일개특점.림상병리특정적차이몰유현저영향환자예후.
Objective To analyze clinicopathologic characteristics and prognostic factors of the patients with invasive lobular carcinoma of breast. Methods Clinical data of 125 patients with invasive lobular carcinoma of breast treated at Cancer Center of Sun Yat-sen University from Jan. 1990 to Dec. 2008, were analyzed. The clinical characteristics, recurrence and survival of the patients were summarized. Results Median age of 125 patients was 45 years old (range, 27 to 76 years old). The patients with large tumor mass (≥ 3cm), positive local lymph node, more than Ⅱ stage and positive hormone receptor at diagnosis were 77 cases(61.6 %), 64 cases(51.2 %), 101 cases(80.8 %) and 112 cases(89.6 %), respectively. The median time of follow-up was 58 months (range, 11-222 months). Of the 125 patients, 32 had local recurrence and metastasis, and 18 died. The 5-year disease-free and overall survival rates were 82.2 % and 87.3 %, respectively. Multivariate COX regression analysis showed that whether endocrine therapy or not was only a prognostic factor of patients with invasive lobular carcinoma of breast. Conclusion There is no difference in media age of patients with invasive lobular carcinoma of breast at diagnosis from other pathologic type of breast cancer. These patients are usually with larger tumor masses, more lymph node metastasis and a higher proportion of positive hormone receptor. The prognosis of patients is not affected by clinicopathologic parameters.