肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2010年
8期
519-520
,共2页
潘燚%李伟雄%谢松喜%林映如%张红丹
潘燚%李偉雄%謝鬆喜%林映如%張紅丹
반일%리위웅%사송희%림영여%장홍단
鼻咽肿瘤%药物疗法,联合
鼻嚥腫瘤%藥物療法,聯閤
비인종류%약물요법,연합
Nasopharyngeal neoplasms%Drug therapy,combination
目的 观察吉西他滨联合奈达铂与紫杉醇治疗对顺铂耐药的转移性鼻咽癌的近期疗效及不良反应.方法 15例顺铂方案化疗失败的转移性鼻咽癌患者.吉西他滨1000 mg/m2,第1、8天;奈达铂70mg/m2,第1天;紫杉醇135 mg/m2,第1天;21 d为1个疗程,疗效评价采用RECIST 3.0标准.结果 全组15例患者CR 1例,PR 5例,SD 6例,PD 3例,总有效(CR+PR)率40.0%.中位TTP为4.7个月,中位生存期为6.3个月.主要不良反应为血液学毒性,Ⅲ+Ⅳ度骨髓抑制的发生率分别为:白细胞减少40.0%、贫血6.7%、血小板减少20.0%.其他不良反应轻微.结论 吉西他滨联合奈达铂与紫杉醇的化疗方案可作为顺铂耐药转移性鼻咽癌的二线方案.
目的 觀察吉西他濱聯閤奈達鉑與紫杉醇治療對順鉑耐藥的轉移性鼻嚥癌的近期療效及不良反應.方法 15例順鉑方案化療失敗的轉移性鼻嚥癌患者.吉西他濱1000 mg/m2,第1、8天;奈達鉑70mg/m2,第1天;紫杉醇135 mg/m2,第1天;21 d為1箇療程,療效評價採用RECIST 3.0標準.結果 全組15例患者CR 1例,PR 5例,SD 6例,PD 3例,總有效(CR+PR)率40.0%.中位TTP為4.7箇月,中位生存期為6.3箇月.主要不良反應為血液學毒性,Ⅲ+Ⅳ度骨髓抑製的髮生率分彆為:白細胞減少40.0%、貧血6.7%、血小闆減少20.0%.其他不良反應輕微.結論 吉西他濱聯閤奈達鉑與紫杉醇的化療方案可作為順鉑耐藥轉移性鼻嚥癌的二線方案.
목적 관찰길서타빈연합내체박여자삼순치료대순박내약적전이성비인암적근기료효급불량반응.방법 15례순박방안화료실패적전이성비인암환자.길서타빈1000 mg/m2,제1、8천;내체박70mg/m2,제1천;자삼순135 mg/m2,제1천;21 d위1개료정,료효평개채용RECIST 3.0표준.결과 전조15례환자CR 1례,PR 5례,SD 6례,PD 3례,총유효(CR+PR)솔40.0%.중위TTP위4.7개월,중위생존기위6.3개월.주요불량반응위혈액학독성,Ⅲ+Ⅳ도골수억제적발생솔분별위:백세포감소40.0%、빈혈6.7%、혈소판감소20.0%.기타불량반응경미.결론 길서타빈연합내체박여자삼순적화료방안가작위순박내약전이성비인암적이선방안.
Objective To assess the short-term effects and adverse reactions of combination regimen of gemcitabine, nedaplatin and paclitaxel for patients with metastatic cisplatin-resistant nasopharyngeal carcinoma (NPC). Methods A total of 15 patients with metastatic cisplatin-resistant NPC were enrolled. All patients were treated with a combination regimen including gemcitabine with 1000 mg/m2 on day 1st and 8th, nedaplatin with 70 mg/m2 on day 1st and paclitaxel with 135 mg/m2 on day 1st, repeated every 21 days. Response was evaluated according to Response Evaluation Criteria in Solid Tumors (RECIST) criteria 3.0. Results The overall response rate was 40.0 %, with a complete response rate of 6.7 % (1/15) and a partial response rate of 33.3 % (5/15). Six patients (40.0 %) had stable disease and 3 patients (20.0 %) had progressive disease. The median time to progression (TTP) was 4.7 months and the median overall survival was 6.3 months. Hematological toxicities were the adverse reaction with 40.0 % of leucopenia, 6.7 % of anemia and 20.0 % thrombocytopenia. One patient needed for platelet transfusion. Other adverse reactions were mild. Conclusion The combination regimen of gemcitabine, nedaplatin and paclitaxel is feasible as second-line chemotherapy in patients with metastatic cisplatin-resistant NPC.