CAJ | 학술논문

目的　探讨具有临床应用前景的移植耐受诱导方法。　方法　以Lewis大鼠和DA大鼠分别作为肾脏移植的受体和供体，采用注射抗淋巴细胞血清（ALS）、输入供体骨髓细胞（BMT）和环磷酰胺（Cp）注射方法进行移植耐受诱导，观察肾脏移植物的存活情况及受体对供体细胞抗原免疫应答改变。　结果　经耐受诱导的大鼠肾脏移植物存活时间明显延长，7只鼠中5只移植物存活73～90 d时仍无排斥反应迹象，混合淋巴细胞反应及诱导迟发型超敏反应表现为供体特异性降低。　结论　诱导免疫耐受预防肾脏移植排斥反应具有重要的临床意义，此方法有一定的临床应用前景。
목적　탐토구유림상 응용전경적이식내수유도방법。　방법　이Lewis대서화DA대서분별 작위신장이식적수체화공체，채용주사항림파세포혈청（ALS）、수입공체골수세포（BMT） 화배 린선알（Cp）주사방법진행이식내수유도，관찰신장이식물적존활정황급수체대공체세포항 원면역응답개변。　결과　경내수유도적대서신장이식물존활시간 명현연장，7지서중5지이식물존활73～90 d시잉무배척반응적상，혼합림파세포반응급유 도지발형초민반응표현위공체특이성강저。　결론　유도면역내수 예방신장이식배척반응구유중요적림상의의，차방법유일정적림상응용전경。
Objective　To investigate a clinically persp ective way of inducing transplantation tolerance.　Methods　Kidney tansplantation model was established using Lewis (RT1l) rats as recipients and DA (RT1a) rats as donor. Before transplantation the recipient rats were condi tioned with anti-lymphothyte serum (ALS) injected for three times, followed by 108 donor bone marrow cells transfusion (BMT) and injection of 100 mg/kg cyclo pho sphamide (CP), survival time of kidney allografts, mixed lymphocyte reaction (MLR ) and delayed-type hypersensitivity (DTH) of recipient to donor spleen cells we re observed and studied.　Results　5 of the 7 kidney allo grafts survived 73 to 90 days without sign of rejection. The donor specific MLR and DTH were suppressed.　Conclusions　Induction of trans plantation tolerance is a prospective way for the prevention of allograft reject ion.