CAJ | 학술논문

[目的]了解中国育龄女性癫痫患者发生生殖内分泌紊乱的相关危险因素,为临床决策提供依据.[方法]收集符合研究标准的102例女性癫痫患者的临床资料,将癫痫起病年龄、发作类型、发作频率、癫痫病程、抗癫痫药物(AED)种类、开始服用AED的年龄、用药持续时间7个因素分组,分析各因素与月经稀发/闭经、多囊卵巢(PCO)、高雄激素血症(HA)、多囊卵巢综合征(PCOC)的关系.[结果]癫痫起病年龄≤14岁者较起病年龄＞14岁者HA高发并具统计学意义;服用丙戊酸钠的患者月经稀发/闭经、PCO、HA、PCOS发生率分别达40.63%、50.00%、15.65%和34.38%,显著高于未用药组及其他用药组.Logistics回归分析结果表明:服用丙戊酸钠是发生生殖内分泌紊乱及PCOS的危险因素.癫痫起病年龄≤14岁是HA的危险因素.[结论]服用丙戊酸钠是中国育龄女性癫痫患者发生生殖内分泌紊乱乃至PCOS的危险因素,癫痫起病年龄≤14岁是HA的危险因素.
[목적]료해중국육령녀성전간환자발생생식내분비문란적상관위험인소,위림상결책제공의거.[방법]수집부합연구표준적102례녀성전간환자적림상자료,장전간기병년령、발작류형、발작빈솔、전간병정、항전간약물(AED)충류、개시복용AED적년령、용약지속시간7개인소분조,분석각인소여월경희발/폐경、다낭란소(PCO)、고웅격소혈증(HA)、다낭란소종합정(PCOC)적관계.[결과]전간기병년령≤14세자교기병년령＞14세자HA고발병구통계학의의;복용병무산납적환자월경희발/폐경、PCO、HA、PCOS발생솔분별체40.63%、50.00%、15.65%화34.38%,현저고우미용약조급기타용약조.Logistics회귀분석결과표명:복용병무산납시발생생식내분비문란급PCOS적위험인소.전간기병년령≤14세시HA적위험인소.[결론]복용병무산납시중국육령녀성전간환자발생생식내분비문란내지PCOS적위험인소,전간기병년령≤14세시HA적위험인소.
[Objective]This study was designed to identify the risk factors related with reproductive endocrinology disorder in Chinese women of child-bearing age with epilepsy.[Methods]The clinical data of 102 women with epilepsy were collected.The patient were grouped according to seven aspects(seizure onset age,seizure type,seizure frequency,duration of epilepsy,AED type,age of start AED therapy and duration of therapy)and the contribution of these factors in development of PCOS and its components were analyzed.[Results]The incidence of hyperandrogenemia in the patients with an early onset age(≤14 years old)was higher than the ones with an onset age＞14 years old.Onset age≤14 was the risk factor of hyperandrogenemia in logistic regression analysis.The incidence of a/oligomenorrhea,polycystic ovaries,hyperandrogenemia and PCOS in the valproate-treated women were 40.63%,50.00%,15.65%,and 34.38%,respectively,which were higher than the no-therapy group and nonvalproate treated group.Valproate therapy was the risk factor of PCOS and its components.[Conclusion]Valproate therapy was the risk factor of PCOS and its components in Chinese women of child-bearing age with epilepsy.Onset age≤14 was the risk factor of hyperandrogenemia.