CAJ | 학술논문

背景:目前神经干细胞应用的最大障碍还在于分化的调控,而对干细胞分化调控机制尚知之甚少.室管膜前下区是目前公认的神经干细胞富集区之一.在此区的神经干细胞可以长距离迁移到嗅球而保持神经干细胞不分化,最后在嗅球分化为中间神经元.骨形成蛋白2及DLX5在室管膜前下区神经干细胞向嗅球迁移分化过程中起着重要作用.目的:研究室管膜前下区神经干细胞的构筑及迁移特点,以及目前国内外有关骨形成蛋白2及DLX5在此区神经干细胞迁移分化中的作用,希望对神经干细胞的分化调控机制有一定的认识.方法:由第一作者利用中文检索词"神经干细胞,室管膜前下区,骨形成蛋白2,DLX5"及英文检索词"neural stem cells,SVZa,BMP-2,DLX5",在PubMed数据库(http://www.ncbi.nlm.nih.gov/PubMed)、中国期刊全文数据库(www.cnki.net/index.htm)、万方数据库(http://www.wanfangdata.com.cn)中检索1997-01/2009-01关于骨形成蛋白2、DLX5在室管膜前下区神经干细胞向神经元分化中作用的文献.排除内容陈旧或重复文献.结果与结论:初检得到121篇文献,中文86篇,英文35篇.最后对符合标准的28篇文献作进一步的分析.结果提示,室管膜前下区神经干细胞具有其独特细胞构筑和长距离迁移的特点,骨形成蛋白2及DLX5在其迁移分化过程中起着重要作用,但其具体作用机制仍不清楚.
배경:목전신경간세포응용적최대장애환재우분화적조공,이대간세포분화조공궤제상지지심소.실관막전하구시목전공인적신경간세포부집구지일.재차구적신경간세포가이장거리천이도후구이보지신경간세포불분화,최후재후구분화위중간신경원.골형성단백2급DLX5재실관막전하구신경간세포향후구천이분화과정중기착중요작용.목적:연구실관막전하구신경간세포적구축급천이특점,이급목전국내외유관골형성단백2급DLX5재차구신경간세포천이분화중적작용,희망대신경간세포적분화조공궤제유일정적인식.방법:유제일작자이용중문검색사"신경간세포,실관막전하구,골형성단백2,DLX5"급영문검색사"neural stem cells,SVZa,BMP-2,DLX5",재PubMed수거고(http://www.ncbi.nlm.nih.gov/PubMed)、중국기간전문수거고(www.cnki.net/index.htm)、만방수거고(http://www.wanfangdata.com.cn)중검색1997-01/2009-01관우골형성단백2、DLX5재실관막전하구신경간세포향신경원분화중작용적문헌.배제내용진구혹중복문헌.결과여결론:초검득도121편문헌,중문86편,영문35편.최후대부합표준적28편문헌작진일보적분석.결과제시,실관막전하구신경간세포구유기독특세포구축화장거리천이적특점,골형성단백2급DLX5재기천이분화과정중기착중요작용,단기구체작용궤제잉불청초.
BACKGROUND:Regulation of neural stem cells differentiation hampers its application,and the regulation mechanism remains poorly understood.Anterior subventricular zone(SVZa)is one of the rich zones of neural stem cells.The neural stem cells at SVZa can immigrate for a long distance with undifferentiated states and finally differentiate into intemeurons at the olfactory bulbs.Bone morphogenetic protein-2(BMP2)and DLX5 play a significant role in immigration and differentiation of neural stem cells at SVZa towards olfactory bulb.OBJECTIVE:To study the feature of construction and immigration of neural stem cells at SVZa,and to review the role of BMP2 and DLX5 in neural stem cells differentiation,in addition,to explore the regulation mechanisms of neural stern cells differentiation.METHODS:Literatures from PubMed database(http://www.ncbi.nlm.nih.gov/PubMed),CNKI database(www.cnki.net/index.htm)and WANFANG database(http://www.wanfangdata.com.cn)published between January 1997 and January 2009 were searched with the key words of"neural stem cells,SVZa,BMP2,and DLX5".The repetitive and obsolete studies were excluded.RESULTS AND CONCLUSION:A total of 121 literatures were selected and primarily collected,including 86 Chinese literatures and 35 English literatures.Finally,according to standardization,28 literatures were further analyzed.Neural stem cells of SVZa have unique construction and can immigrate for a long distance.BMP2 and DLX5 play a significant role in neuronal immigration and differentiation of the NSCs of SVZa,but the detailed mechanism of BMP2 and DLX5 in SVZa is not clear.