CAJ | 학술논문

胃肠道间质瘤(GIST)是起源于间叶组织的肿瘤,其特异性的存在c-kit及血小板源性生长因子受体-α(PDGFRA)基因突变.大多数GIST都具有恶性倾向.肿瘤体积、核分裂象作为评估肿瘤预后的两大基本因素,在很大程度上取决于肿瘤的部位.在分子生物学方面,c-kit基因主要突变位点为外显子11、9、13、17;PDGFRA基因突变位点则为外显子18、12、14.不同突变位点及不同突变类型与肿瘤良恶性预后有着密切关系.免疫组化、组织学同样是判断GIST预后两大重要因素.
위장도간질류(GIST)시기원우간협조직적종류,기특이성적존재c-kit급혈소판원성생장인자수체-α(PDGFRA)기인돌변.대다수GIST도구유악성경향.종류체적、핵분렬상작위평고종류예후적량대기본인소,재흔대정도상취결우종류적부위.재분자생물학방면,c-kit기인주요돌변위점위외현자11、9、13、17;PDGFRA기인돌변위점칙위외현자18、12、14.불동돌변위점급불동돌변류형여종류량악성예후유착밀절관계.면역조화、조직학동양시판단GIST예후량대중요인소.
Gastrointestinal stromal tumor( CIST) is the most common form of mesenchymal tumor of the gastrointestinal tract. Most GISTs characteristically harbor activating mutations of c-kit or PDCFRA( platelet derived growth factor receptor alpha, PDGFRA). All CISTs should be regarded having malignant potential. Tumor size and mitotic count, as two basic progonstic factors for primary CISTs, are largely site dependent. Most c-kit mutations have been found in exon 11,9,13,17 while PDGFRA mutations re found in exon 18,12,14.The sites and types of mutions are associated with the prognosis of CIST. Histopathology and immunohistochem-istry are another two factors predicting tumor outcome.