国际放射医学核医学杂志
國際放射醫學覈醫學雜誌
국제방사의학핵의학잡지
INTERNATIONAL JOURNAL OF RADIATION MEDICINE AND NUCLEAR MEDICINE
2009年
1期
26-29
,共4页
宁艳丽%晋建华%张宏%田梅%姚琼%占宏伟%赵春雷%许唯%叶小娟%李晶
寧豔麗%晉建華%張宏%田梅%姚瓊%佔宏偉%趙春雷%許唯%葉小娟%李晶
저염려%진건화%장굉%전매%요경%점굉위%조춘뢰%허유%협소연%리정
癫痫%正电子发射体层摄影术%统计参数图5
癲癇%正電子髮射體層攝影術%統計參數圖5
전간%정전자발사체층섭영술%통계삼수도5
Epilepsy%Positron-emission tomography%Statistical parametric mapping 5
目的 探讨统计参数图5(SPM5)软件及不同参数设定在癫痫患者脑PET图像分析中的应用价值.方法 癫痫病例组17例,均经临床综合确诊为癫痫,对照组为17例同期健康体检者,对研究对象行18F-氟脱氧葡萄糖PET脑显像.在SPM5平台下,设置不同置信水平(P)与三维像素水平(k),对癫痫病灶部位代谢减低区个数与脑部所有减低区个数的百分比进行统计学分析.结果 PET示病灶多位于颞叶;病灶侧及其对侧与小脑的T/NT值分别为1.07±0.24和1.27±0.18,两者具有统计学差异(t=1.87,P<0.05).SPM5软件处理,病灶主要集中于颞叶19区、21区和39区及顶叶和枕叶7区、19区、31区、40区和47区;选取不同k值,所得半定量结果分别为(27±22)%、(29±24)%、(32±23)%、(35±27)%及(39±31)%,组间无差异(F=0.59,P>0.05);选取不同P值,半定量结果分别为(42±30)%、(29±25)%及(26±21)%,组间存在差异(F=3.60,P<0.05);置信水平P与上述半定量结果之间存在直线回归关系(回归系数b=18.24,t=2.57,P<0.05).结论 SPM5软件分析PET原始图像时,置信水平P对软件分析结果有影响,P取值越小,软件分析所得结果越优.SPM5能更加客观准确定位病灶.
目的 探討統計參數圖5(SPM5)軟件及不同參數設定在癲癇患者腦PET圖像分析中的應用價值.方法 癲癇病例組17例,均經臨床綜閤確診為癲癇,對照組為17例同期健康體檢者,對研究對象行18F-氟脫氧葡萄糖PET腦顯像.在SPM5平檯下,設置不同置信水平(P)與三維像素水平(k),對癲癇病竈部位代謝減低區箇數與腦部所有減低區箇數的百分比進行統計學分析.結果 PET示病竈多位于顳葉;病竈側及其對側與小腦的T/NT值分彆為1.07±0.24和1.27±0.18,兩者具有統計學差異(t=1.87,P<0.05).SPM5軟件處理,病竈主要集中于顳葉19區、21區和39區及頂葉和枕葉7區、19區、31區、40區和47區;選取不同k值,所得半定量結果分彆為(27±22)%、(29±24)%、(32±23)%、(35±27)%及(39±31)%,組間無差異(F=0.59,P>0.05);選取不同P值,半定量結果分彆為(42±30)%、(29±25)%及(26±21)%,組間存在差異(F=3.60,P<0.05);置信水平P與上述半定量結果之間存在直線迴歸關繫(迴歸繫數b=18.24,t=2.57,P<0.05).結論 SPM5軟件分析PET原始圖像時,置信水平P對軟件分析結果有影響,P取值越小,軟件分析所得結果越優.SPM5能更加客觀準確定位病竈.
목적 탐토통계삼수도5(SPM5)연건급불동삼수설정재전간환자뇌PET도상분석중적응용개치.방법 전간병례조17례,균경림상종합학진위전간,대조조위17례동기건강체검자,대연구대상행18F-불탈양포도당PET뇌현상.재SPM5평태하,설치불동치신수평(P)여삼유상소수평(k),대전간병조부위대사감저구개수여뇌부소유감저구개수적백분비진행통계학분석.결과 PET시병조다위우섭협;병조측급기대측여소뇌적T/NT치분별위1.07±0.24화1.27±0.18,량자구유통계학차이(t=1.87,P<0.05).SPM5연건처리,병조주요집중우섭협19구、21구화39구급정협화침협7구、19구、31구、40구화47구;선취불동k치,소득반정량결과분별위(27±22)%、(29±24)%、(32±23)%、(35±27)%급(39±31)%,조간무차이(F=0.59,P>0.05);선취불동P치,반정량결과분별위(42±30)%、(29±25)%급(26±21)%,조간존재차이(F=3.60,P<0.05);치신수평P여상술반정량결과지간존재직선회귀관계(회귀계수b=18.24,t=2.57,P<0.05).결론 SPM5연건분석PET원시도상시,치신수평P대연건분석결과유영향,P취치월소,연건분석소득결과월우.SPM5능경가객관준학정위병조.
Objective To investigate the value of statistical parametric mapping 5 (SPM5) and its parameter settings in analysis of PET imaging for epilepsy patients. Methods Seventeen epilepsy patients and seventeen controls were scanned with PET. The datns were analyzed using PET and SPM5 with qualitative and semiquantitative analysis, statistical analysis of the percentage (numbers of agent distribution decreasing in focus to brain) for different parameters combinations, which were value adjustment to contral-p and voxels-k. Results There was decreasing of agent distribution at temporal lobe in epilepsy patients detecting with PET; the T/NT of focus to cerebellum was 1.07±0.24, the T/NT of normal tissue in opposite side to cerebellum was 1.27±0.18, there was a significant difference (t=1.87, P<0.05). Dealing with SPM5, there was more significant decreasing of agent in regions 19, 21, 39 of temporal lobe, regions 7, 19, 31, 40, 47 of parietal lobe and occipital lobe in epilepsy patients. With different value of k, the percentage was (27±22)%, (29±24)%, (32±23)%, (35±27)%, (39±31)%respectively, there was not significant difference (F=0.59, P>0.05) ; for different value of p, the percentage was (42±30) %, (29±25) %, (26±21) % respectively, with a significant difference (F=3.60, P<0.05); there was linear regression in value adjustment to contral-p and the percentage(b=-18.24, t=2.57, P<0.05). Conclusions Semiquantitative analysis by SPM5, the setting of value adjustment to contral-p would affect the results, the smaller of value adjustment to contral-p, the better of the result. SPM5 would be more objective and accurate to locate the focuses.
