CAJ | 학술논문

目的比较载阿仑膦酸钠丙烯酸骨水泥与皮下注射阿仑膦酸钠抑制钛磨眉诱导的骨溶解的效果.方法 48只成年雄性新西兰兔随机均分为无钛磨屑且无阿仑膦酸钠组(A组),有钛磨屑注射且无阿仑膦酸钠组(B组),钛磨屑分别注射0.1%、0.5%、1.0%载阿仑膦酸钠丙烯酸骨水泥组(C、I)、E组),钛磨屑注射且皮下手射阿仑膦酸钠组(F组),每组8只.将载阿仑膦酸钠骨水泥植入兔股骨远端.制备磨屑诱导骨溶解动物模型.术后8周对股骨行组织形态学分析、骨密度(bone mineral density,BMD)测定及界面力学测试结果 B组假体周围可见明显的骨溶解,而C、D、E、F组骨溶解明显少于B组.B组假体周围BMD和骨-骨水泥界面抗剪强度分别较A组下降17%和56%;D组假体周围BMD和界面抗剪强度较B组分别增加29%和62%;E组假体周围BMD和界画抗剪强度较B组分别增加37%和29%;F组假体周围BMD和界面抗剪强度较B组分别增加51%和69%;C组、D组、E组分别与F组比较,假体周围BMD和界面抗剪强度的差异均无统计学意义.结论载阿仑瞵酸钠丙烯酸骨水泥与皮下注射阿仑瞵酸钠均可在一定程度上抑制磨屑诱导的骨吸收,增强界画抗剪强度.
목적 비교재아륜련산납병희산골수니여피하주사아륜련산납억제태마미유도적골용해적효과.방법 48지성년웅성신서란토수궤균분위무태마설차무아륜련산납조(A조),유태마설주사차무아륜련산납조(B조),태마설분별주사0.1%、0.5%、1.0%재아륜련산납병희산골수니조(C、I)、E조),태마설주사차피하수사아륜련산납조(F조),매조8지.장재아륜련산납골수니식입토고골원단.제비마설유도골용해동물모형.술후8주대고골행조직형태학분석、골밀도(bone mineral density,BMD)측정급계면역학측시결과 B조가체주위가견명현적골용해,이C、D、E、F조골용해명현소우B조.B조가체주위BMD화골-골수니계면항전강도분별교A조하강17%화56%;D조가체주위BMD화계면항전강도교B조분별증가29%화62%;E조가체주위BMD화계화항전강도교B조분별증가37%화29%;F조가체주위BMD화계면항전강도교B조분별증가51%화69%;C조、D조、E조분별여F조비교,가체주위BMD화계면항전강도적차이균무통계학의의.결론 재아륜린산납병희산골수니여피하주사아륜린산납균가재일정정도상억제마설유도적골흡수,증강계화항전강도.
Objective To investigate the effects of locally and systemically administered alendronate on wear-debris induced osteolysis in vivo. Methods Endotnxin-free titanium particles were injected into rabbit femurs prior to insertion of a non-weight-bearing polymethylmethacrylate plug into the distal femur canal. Then the particles were repeatedly injected into the knee 2, 4 and 6 weeks after the implantation. Alendronate was incorporated into bone cement for local delivery at three different concentrations [0.1, 0.5, and 1.0 weight%(wt%)]. For systemic delivery, alendronate was subcutaneously injected ( 1.0 mg· kg-1·week-1).Results Eight weeks after operation, there was significant evidence of osteolysis surrounding the plug in the control group, while markedly-blocked osteolysis was noted in the local delivery group (0.5 wt% and 1.0 wt%), and the systemic delivery group. It was found that alendronate had improved peri-prosthetic bone mineral density in a dose-effect model. Notably, no significant difference was found between local delivery of 0.5 wt% alendronate and systemic delivery in bone mineral density and implant fixation. Conclusion Alendronate-loaded bone cement (0.5 wt% ) may be as effective as the systemic delivery in inhibiting titanium particle-induced osteolysis.