CAJ | 학술논문

目的探索放射辐照对预防肌腱粘连的影响.方法 30只鸡按时间2、4、8周随机分成3组,每组10只,设左足为实验组,右足为对照组.切断鸡双足第2、3、4趾趾深屈肌腱,用8字法缝合肌腱,术后不做外固定.左足于术后24 h内采用电子束照射(总剂量15 Gy),右足不作特殊处理.于术后2、4、8周分别做大体观察、生物力学测试、病理组织学观察.结果发现在大体粘连性状、关节屈曲角度、肌腱滑动距离、病理组织学上,辐照实验足和未照射对照足差异有统计学意义(P＜0.01);肌腱最大抗断裂负荷上两足差异无统计学意义(P＞0.05).结论肌腱术后放射辐照能明显抑制胶原过分增生,对预防肌腱损伤术后粘连有效,为临床应用提供实验模型.
목적 탐색방사복조대예방기건점련적영향.방법 30지계안시간2、4、8주수궤분성3조,매조10지,설좌족위실험조,우족위대조조.절단계쌍족제2、3、4지지심굴기건,용8자법봉합기건,술후불주외고정.좌족우술후24 h내채용전자속조사(총제량15 Gy),우족불작특수처리.우술후2、4、8주분별주대체관찰、생물역학측시、병리조직학관찰.결과 발현재대체점련성상、관절굴곡각도、기건활동거리、병리조직학상,복조실험족화미조사대조족차이유통계학의의(P＜0.01);기건최대항단렬부하상량족차이무통계학의의(P＞0.05).결론 기건술후방사복조능명현억제효원과분증생,대예방기건손상술후점련유효,위림상응용제공실험모형.
Objective To explore the role of electron beam in preventing tendon adhesion. Methods Based on the postoperative observation durations of 2, 4 and 8 weeks respectively, 30 healthy chickens were randomly divided into 3 groups with 10 each. The left foot was assigned as the experimental side, while the right foot as the control side. Flexor digitorum profundus tendons at zone Ⅱ in the 2nd , 3rd and 4th toes of both feet were transected and repaired with figure-of-eight suture. The chickens were raised cage free without immobilization after the surgery. Within 24 hours after the surgery electron beam (total 15 Gy) was applied to radiate the left leg. The right leg was left untreated. Gross observation, biomechanical tests and histological examination of the repaired tendons were carried out at 2, 4 and 8 weeks postoperatively. Results Tendons from the radiated side were significantly better in terms of adhesion, joint flexion angle, tendon excursion and tissue histology ( P ＜ 0.01 ). However the difference of the tensile strength was not significant between the experimental side and control side ( P ＞ 0.05). Conclusion Electron beam radiation following tendon repair can inhibit collagen proliferation and thus effectively prevent tendon adhesion. This provides an experimental model for the clinical application of electron beam.