安徽医学
安徽醫學
안휘의학
ANHUI MEDICAL JOURNAL
2009年
7期
706-708
,共3页
邹瑞%程光亮%潘林宏%孙俊杰
鄒瑞%程光亮%潘林宏%孫俊傑
추서%정광량%반림굉%손준걸
125Ⅰ-HPNS-TOC%生长抑素受体%靶向%放射性药物
125Ⅰ-HPNS-TOC%生長抑素受體%靶嚮%放射性藥物
125Ⅰ-HPNS-TOC%생장억소수체%파향%방사성약물
125Ⅰ-HPNS-TOC%Somatestatin%Target%Radiotherapoutic
目的 研究联接标记法制备的125Ⅰ-HPNS-TOC与小细胞肺癌株NCI-H446的受体结合特性及其在小鼠体内的分布.方法 125Ⅰ-HPNS-TOC与NCI-H446进行受体分析,并进行昆明鼠体内分布实验.结果 125Ⅰ-HPNS-TOC与NCI-H446上的SSTR结合的具有高亲和力,在小鼠体内主要经消化系统和泌尿系统排出体外.结论 125Ⅰ-HPNS-TOC与SSTR结合力高,有望成为生长抑素受体阳性肿瘤的靶向放射性药物.
目的 研究聯接標記法製備的125Ⅰ-HPNS-TOC與小細胞肺癌株NCI-H446的受體結閤特性及其在小鼠體內的分佈.方法 125Ⅰ-HPNS-TOC與NCI-H446進行受體分析,併進行昆明鼠體內分佈實驗.結果 125Ⅰ-HPNS-TOC與NCI-H446上的SSTR結閤的具有高親和力,在小鼠體內主要經消化繫統和泌尿繫統排齣體外.結論 125Ⅰ-HPNS-TOC與SSTR結閤力高,有望成為生長抑素受體暘性腫瘤的靶嚮放射性藥物.
목적 연구련접표기법제비적125Ⅰ-HPNS-TOC여소세포폐암주NCI-H446적수체결합특성급기재소서체내적분포.방법 125Ⅰ-HPNS-TOC여NCI-H446진행수체분석,병진행곤명서체내분포실험.결과 125Ⅰ-HPNS-TOC여NCI-H446상적SSTR결합적구유고친화력,재소서체내주요경소화계통화비뇨계통배출체외.결론 125Ⅰ-HPNS-TOC여SSTR결합력고,유망성위생장억소수체양성종류적파향방사성약물.
Objective To investigate characteristic of bound to the receptor within NCI - H446 cell lines of 125Ⅰ-HPNS-TOC, la-beled with conjugation labeling techniques, and its biodistribution in mice. Methods 125 Ⅰ-HPNS - TOC, radioligand, detected using radi-oligand binding assay with somatostatin receptor(SSTR) positive NCI-H446 cell lines. Its biodistribution in normal mice was analyzed. Re-suits 125Ⅰ - HPNS - TOC had high affinity to SSTR within NCI - H446 cell lines. It was excreted by gastrointestinal - liver and kidney.Conclusion 125-HPNS-TOC has high affinity to SSTR. Our experiment indicate that 125Ⅰ-HPNS-TOC is a promising radiotherapeutic for SSTR positive tumors.
