中国组织工程研究与临床康复
中國組織工程研究與臨床康複
중국조직공정연구여림상강복
JOURNAL OF CLINICAL REHABILITATIVE TISSUE ENGINEERING RESEARCH
2009年
33期
6418-6422
,共5页
自体移植%软骨细胞%骨缺损
自體移植%軟骨細胞%骨缺損
자체이식%연골세포%골결손
背景:由于关节软骨再生修复能力有限,自体软骨细胞移植技术为关节软骨损伤的修复提供了较好的修复材料.目的:多中心评估自体软骨细胞移植的短期疗效与安全性.设计、时间及地点:自身前后对照观察,于2001-03/2006-04在韩国80所附属医院完成.对象:软骨缺损患者261例,男169例,女92例,年龄15～70岁,平均36.47岁.软骨缺损面积2.0～20.0 cm2.其中股骨髁损伤215例,滑车30例,髌骨25例,胫骨2例.方法:取关节非负重区软骨组织200～300 mg,体外培养扩增后将软骨细胞植入患者关节缺损区.于移植后6个月对所有患者进行随访,膝关节功能评估标准采用美国膝关节协会评分系统[Knee society score-A(KSS-A)和Knee society score-B(KSS-B)].主要观察指标:自体软骨细胞膝关节缺损区移植后KSS-A和KSS-B评分.结果:获得随访患者261例.患者移植前KSS-A评分为63.55±18.47,移植后6个月为88.74±11,47,差异有显著性意义(P＜0.05)移植前KSS-B评分为59.56±24.92,移植后6个月为85.13±14.67,差异有显著性意义(P＜0.05).患者移植前后膝关节疼痛、活动度、前后稳定性、屈曲挛缩、伸直迟滞、行走能力和上下楼能力均明显改善(P＜0.05).综合评价移植有效率为97.3%,优良率为89.3%.结论:自体软骨细胞移植可有效的治疗关节软骨缺损,促进膝关节功能的恢复.
揹景:由于關節軟骨再生脩複能力有限,自體軟骨細胞移植技術為關節軟骨損傷的脩複提供瞭較好的脩複材料.目的:多中心評估自體軟骨細胞移植的短期療效與安全性.設計、時間及地點:自身前後對照觀察,于2001-03/2006-04在韓國80所附屬醫院完成.對象:軟骨缺損患者261例,男169例,女92例,年齡15～70歲,平均36.47歲.軟骨缺損麵積2.0～20.0 cm2.其中股骨髁損傷215例,滑車30例,髕骨25例,脛骨2例.方法:取關節非負重區軟骨組織200～300 mg,體外培養擴增後將軟骨細胞植入患者關節缺損區.于移植後6箇月對所有患者進行隨訪,膝關節功能評估標準採用美國膝關節協會評分繫統[Knee society score-A(KSS-A)和Knee society score-B(KSS-B)].主要觀察指標:自體軟骨細胞膝關節缺損區移植後KSS-A和KSS-B評分.結果:穫得隨訪患者261例.患者移植前KSS-A評分為63.55±18.47,移植後6箇月為88.74±11,47,差異有顯著性意義(P＜0.05)移植前KSS-B評分為59.56±24.92,移植後6箇月為85.13±14.67,差異有顯著性意義(P＜0.05).患者移植前後膝關節疼痛、活動度、前後穩定性、屈麯攣縮、伸直遲滯、行走能力和上下樓能力均明顯改善(P＜0.05).綜閤評價移植有效率為97.3%,優良率為89.3%.結論:自體軟骨細胞移植可有效的治療關節軟骨缺損,促進膝關節功能的恢複.
배경:유우관절연골재생수복능력유한,자체연골세포이식기술위관절연골손상적수복제공료교호적수복재료.목적:다중심평고자체연골세포이식적단기료효여안전성.설계、시간급지점:자신전후대조관찰,우2001-03/2006-04재한국80소부속의원완성.대상:연골결손환자261례,남169례,녀92례,년령15～70세,평균36.47세.연골결손면적2.0～20.0 cm2.기중고골과손상215례,활차30례,빈골25례,경골2례.방법:취관절비부중구연골조직200～300 mg,체외배양확증후장연골세포식입환자관절결손구.우이식후6개월대소유환자진행수방,슬관절공능평고표준채용미국슬관절협회평분계통[Knee society score-A(KSS-A)화Knee society score-B(KSS-B)].주요관찰지표:자체연골세포슬관절결손구이식후KSS-A화KSS-B평분.결과:획득수방환자261례.환자이식전KSS-A평분위63.55±18.47,이식후6개월위88.74±11,47,차이유현저성의의(P＜0.05)이식전KSS-B평분위59.56±24.92,이식후6개월위85.13±14.67,차이유현저성의의(P＜0.05).환자이식전후슬관절동통、활동도、전후은정성、굴곡련축、신직지체、행주능력화상하루능력균명현개선(P＜0.05).종합평개이식유효솔위97.3%,우량솔위89.3%.결론:자체연골세포이식가유효적치료관절연골결손,촉진슬관절공능적회복.
BACKGROUND:The regeneration ability of articular cartilage is limited.However,the emerging of tissue regeneration based on the use of autologous cells appears to offer great promise in repairing articular cartilage defects.OBJECTIVE:To evaluate the short-term effectiveness and safety of autologous chondrocyte implantation (ACI).DESIGN,TIME AND SETTING:A prospective study was performed at the eighty university hospitals and general hospitals in Korea from March 2001 to April 2006.PARTICIPANTS:Two hundred and sixty-one patients with articular cartilage injury of the knee were selected,including 169 males,92 females,with the mean age of 36.47 years (ranged:15-70 yeats old),and the mean size of chondral defect was 4.91 cm2 (ranged:2.0-20.0 cm2).Totally 215 cases were femoral condyle injury,30 cases with trochlear,25 cases with patellar,and 2 cases with tibia defects.METHODS:A total of 200-300 mg of cartilage tissue was obtained from a non-weight-bearing portion of the knee,followed by in society score after ACI was evaluated by Knee Society Score-A (KSS-A)and Knee Society Score-B (KSS-B)system.MAIN OUTCOME MEASURES:KSS-A and KSS-B score of defected areas after ACI.RESULTS:All patients Received: followed-up without any loss.The KSS-A was 63.55±18.47 and 88.74±11.47 prior to and at 6 months after implantation,the difference had significance (P＜0.05).The KSS-B was 59.56±24.92 and 85.13±14.67 respectively prior to and at 6 months after implantation,which had obviously difference (P＜0.05).The joint pain,activity,stability,flexion contracture,locomotor activity and stair climbing were obviously improved.The effective rate was 97.3% and excellent and good rate was 89.3%.CONCLUSION:ACI can achieve a good result in treating knee articular cartilage defects,which can encourage the recover of knee function.
