化学世界
化學世界
화학세계
CHEMICAL WORLD
2010年
2期
108-109,128
,共3页
烟酸%葫芦巴碱%合成
煙痠%葫蘆巴堿%閤成
연산%호호파감%합성
nicotinic acid%trigonelline%synthesis
以烟酸和硫酸二甲酯为原料合成葫芦巴碱,并与硫酸成盐.对氢氧化钠用量,硫酸二甲酯用量,反应温度三因素进行考察得出最优工艺条件.结果最佳工艺条件为n(NaOH):n(烟酸)=2.2:1,n(硫酸二甲酯):n(烟酸)=1.3:1(摩尔比),反应温度45～50℃,反应时间4 h.硫酸葫芦巴碱的收率达92%以上,纯度98.47%.
以煙痠和硫痠二甲酯為原料閤成葫蘆巴堿,併與硫痠成鹽.對氫氧化鈉用量,硫痠二甲酯用量,反應溫度三因素進行攷察得齣最優工藝條件.結果最佳工藝條件為n(NaOH):n(煙痠)=2.2:1,n(硫痠二甲酯):n(煙痠)=1.3:1(摩爾比),反應溫度45～50℃,反應時間4 h.硫痠葫蘆巴堿的收率達92%以上,純度98.47%.
이연산화류산이갑지위원료합성호호파감,병여류산성염.대경양화납용량,류산이갑지용량,반응온도삼인소진행고찰득출최우공예조건.결과최가공예조건위n(NaOH):n(연산)=2.2:1,n(류산이갑지):n(연산)=1.3:1(마이비),반응온도45～50℃,반응시간4 h.류산호호파감적수솔체92%이상,순도98.47%.
Trigonelline was synthesized using nicotinic acid and(CH_3)_2SO_4 as raw material and water as solvent.Then,trigonelling sulfate was obtained by adding sulfuric acid.The effect of the quantity of NaOH and(CH_3)_2 SO_4,and reaction temperature on the yield of trigonelline was studied.The optimum conditions were as follows:NaOH:nicotinic acid=2.2:1,(CH_3)_2SO_4:nicotinic acid=1.3:1(n:n);reaction temperature,45～50℃;reaction time,4 h.The yietd of trigonelline sulfate was more than 92% and its purity was 98.47%.
