CAJ | 학술논문

浆细胞样树突状细胞(PDC)来源于淋巴系干细胞,其表面标志、功能有别于髓系DC,不仅在抗病毒免疫中发挥重要作用,而且通过多种途径诱导T细胞失能和调节性T细胞的形成,从而参与免疫耐受的诱导.PDC诱导T细胞免疫耐受的分子机制与吲哚胺2,3-双加氧酶(IDO)-色氨酸代谢通路和具有抑制功能的膜分子密切相关.深入阐明PDC诱导耐受的机制,将为免疫耐受异常相关的疾病的治疗提供新方案.
장세포양수돌상세포(PDC)래원우림파계간세포,기표면표지、공능유별우수계DC,불부재항병독면역중발휘중요작용,이차통과다충도경유도T세포실능화조절성T세포적형성,종이삼여면역내수적유도.PDC유도T세포면역내수적분자궤제여신타알2,3-쌍가양매(IDO)-색안산대사통로화구유억제공능적막분자밀절상관.심입천명PDC유도내수적궤제,장위면역내수이상상관적질병적치료제공신방안.
Plasmacytoid dendritic cells (PDC) derive from a common lymphoid progenitor.The phenotypic features and functions of PDC are distinct from that of conventional myeloid DCs.PDC have been proven to play a important role in antiviral immune response.They also induce T cells anergy and the generation of regulatory T cells for immune tolerance.The mechanisms of immune tolerance is associated with the indoleamine 2,3-dioxygenase (IDO)-tryptophan metabolism pathway and the inhibitory membrane molecules.To elucidate the mechanisms immune tolerance induced by PDC may provide novel therapeutic approaches for diseases related to abnormal immune tolerance,such as persistent infection,tumor and autoimmune diseases.