CAJ | 학술논문

过敏性紫癜(HSP)是儿童期较为常见的小血管性血管炎,其病因及发病机制尚不明确,近年来有研究表明某些细胞因子的基因多态性与HSP的发病机制、易感性、病理进展及预后等密切相关,如白细胞介素基因、细胞粘附分子基因、血管内皮生长因子基因、转化生长因子基因、肿瘤坏死因子基因等.因此对与HSP相关的细胞因子基因多态性进行综合分析将有着重要意义,为今后临床上从基因水平认识HSP疾病的本质及开发新的研究和新的治疗方案提供了重要的依据.
과민성자전(HSP)시인동기교위상견적소혈관성혈관염,기병인급발병궤제상불명학,근년래유연구표명모사세포인자적기인다태성여HSP적발병궤제、역감성、병리진전급예후등밀절상관,여백세포개소기인、세포점부분자기인、혈관내피생장인자기인、전화생장인자기인、종류배사인자기인등.인차대여HSP상관적세포인자기인다태성진행종합분석장유착중요의의,위금후림상상종기인수평인식HSP질병적본질급개발신적연구화신적치료방안제공료중요적의거.
Henoch-Schonlein purpura (HSP) is the most common vasculitis affecting mainly children and its etiology and pathogenesis are still unclear. In recent years, some studies have shown that the polymorphisms of certain cytokine genes, e. g. , Interleukin gene, cell adhesion molecule gene, vascular endothelial growth factor gene, transforming growth factor gene, etc. , are correlated with the pathogenesis, susceptibility, progress in pathology and prognosis of HSP. Therefore, comprehensive analysis of the association between cytokine gene polymorphisms and HSP would be important may provide clues for clinical to understanding the nature of HSP on the genetic level and new research and new treatment in future.