CAJ | 학술논문

HIV-1的复制及其所致的病理变化与细胞周期紊乱、细胞凋亡密切相关.p21是已知的具有最广泛激酶抑制活性的细胞周期抑制蛋白,它还参与细胞凋亡、老化等.p21成为HIV-1利用宿主生化机制进行复制的关键靶点.此文就近年来p21与HIV-1感染关系的研究进展做了简要综述.
HIV-1적복제급기소치적병리변화여세포주기문란、세포조망밀절상관.p21시이지적구유최엄범격매억제활성적세포주기억제단백,타환삼여세포조망、노화등.p21성위HIV-1이용숙주생화궤제진행복제적관건파점.차문취근년래p21여HIV-1감염관계적연구진전주료간요종술.
The life cycle of HIV-1 and the pathological change produced by HIV-1 are associated tightly with the disorders of host cell cycle and apoptosis, p21 is a well-known protein which has wide eyehn-dependent kinase inhibitive activity, and it also involves the process of cell apoptosis and senescence. For this reason, p21 becomes the important target by HIV-1 to complete virus life cycle with the help of host biochemical mechanism. Here the state of its structure and function feature, relations with cell cycle and apoptosis and roles in the HIV-1 infection are reviewed in the article.