CAJ | 학술논문

目的研究幽门螺杆菌(Hp)感染及血清胃泌素水平与结直肠癌发病的相关性.方法结直肠癌组47例及经全结肠镜检查未见明显异常或仅轻度慢性炎性反应的对照组30例,EUSA法检测血清HpIgG,以及14C尿素呼气试验和/或快速尿素酶试验,三者中至少两项阳性为存在Hp感染;入选者均用ELISA法检测其空腹血清胃泌素水平.结果结直肠癌组Hp感染率[61.7%(29/47)]显著高于对照组[36.7%(11/30)](P<0.05);其中远侧结直肠癌患者较对照组及结直肠癌组的女性患者较对照组的女性患者均有增高,差异有统计学意义(P<0.05).结直肠癌组血清胃泌素水平[(139.7±53.3)nv/L]显著高于对照组[(89.5±26.1)mg/L](P<0.01);其中以远侧结直肠癌患者为著.结论高Hp感染率及其引发的血清胃泌素水平增高,与结直肠癌的发病呈正相关.
목적 연구유문라간균(Hp)감염급혈청위비소수평여결직장암발병적상관성.방법 결직장암조47례급경전결장경검사미견명현이상혹부경도만성염성반응적대조조30례,EUSA법검측혈청HpIgG,이급14C뇨소호기시험화/혹쾌속뇨소매시험,삼자중지소량항양성위존재Hp감염;입선자균용ELISA법검측기공복혈청위비소수평.결과 결직장암조Hp감염솔[61.7%(29/47)]현저고우대조조[36.7%(11/30)](P<0.05);기중원측결직장암환자교대조조급결직장암조적녀성환자교대조조적녀성환자균유증고,차이유통계학의의(P<0.05).결직장암조혈청위비소수평[(139.7±53.3)nv/L]현저고우대조조[(89.5±26.1)mg/L](P<0.01);기중이원측결직장암환자위저.결론 고Hp감염솔급기인발적혈청위비소수평증고,여결직장암적발병정정상관.
Objective To investigate the relationship among Helicobacter pylori (Hp) infection, serum gastrin level and colorectal carcinoma. Methods Fasting serum samples from 47 consecutive patients with colorectal carcinoma and 30 demoographically matched colonoscopy-negative controls were detected for serum gastrin levels and IgG antibodies against Hp (Hp IgG) by enzyme linked immunosorbent assay. Some of them accepted 14C urease breath test and/or rapid urease test after undergoing endoscopy. Hp infection was affirmed when at least two of the three tests were positive. Results The Hp infection incidence was significantly higher in patients with eoloreetal carcinoma (61.7%, 29/47) as compared with controls (36.7%, 11/30) (P<0.05). The Hp infection incidence in distal distribution of carcinoma was higher than that in controls, and in female carcinoma was higher than that in female controls(P <0.05). Mean fasting serum gas-trin levels were significantly higher in patients with coloreetal carcinoma[(139.7±53.3 ) ng/L]than those in controls [(89.5±26.1 ) ng/L] (P < 0.01 ). There was a significant association between hypergastrinemia and distal distribution of carcinoma. Conclusion Increasing serum gastrin levels, higher Hp infection incidence has a positive relationship with colorectal carcinoma.