CAJ | 학술논문

目的探讨乳腺癌转移抑制基因1( BRMS1)在结肠癌组织中的表达及其意义.方法采用免疫组化二步法,检测46例结肠癌组织及癌旁组织中BRMS1蛋白的表达情况,并结合临床病理特征分析其临床意义.结果结肠癌组织与癌旁组织中BRMS1的阳性表达率分别为34.8％(16/46)、84.8％( 39/46),差异有统计学意义(x2 =23.92,p ＜0.01):BRMS1表达与结肠癌肿块大小、临床分期、淋巴结转移状态密切相关(x2=6.02、4.28、4.35,均P＜O.01),与患者年龄、病理类型等无关.结论 BRMS1在结肠癌的转移过程中可能起到抑制作用,检测结肠癌组织中BRMS1蛋白的表达,有助于判断其预后.
목적 탐토유선암전이억제기인1( BRMS1)재결장암조직중적표체급기의의.방법 채용면역조화이보법,검측46례결장암조직급암방조직중BRMS1단백적표체정황,병결합림상병리특정분석기림상의의.결과 결장암조직여암방조직중BRMS1적양성표체솔분별위34.8％(16/46)、84.8％( 39/46),차이유통계학의의(x2 =23.92,p ＜0.01):BRMS1표체여결장암종괴대소、림상분기、림파결전이상태밀절상관(x2=6.02、4.28、4.35,균P＜O.01),여환자년령、병리류형등무관.결론 BRMS1재결장암적전이과정중가능기도억제작용,검측결장암조직중BRMS1단백적표체,유조우판단기예후.
Objective To investigate the expression and clinical significance of BRMS1 ( breast cancer metastasis suppressorl ) protein in colon cancer.Methods The expression of BRMS1 protein was detected by using EliVision immunohistochemical techniques in 46 cases of colon cancer,and adjacent non cancerous colon tissues.The clinical significance with histopathologic records was aralyzed.Results The expression levels of BRMS1 ( 34.8％ ) in the colon cancer tissues was significantly lower than those of adjacent non cancerous colon tissues( x2 =23.92,P ＜0.01 ).The expression of BRMSl was significantly correlated with tumor size,clinical stage,and lymph node status (x2 =6.02,4.28,4.35,all P＜0.01) ;BRMS1 had no correlation with age,pathological type.Conclusion BRMS1 might synergistically promote the metastasis of colon cancer.Detection of the expression of BRMS1 may be hdpful in determineing the prognosis of colon cancer.