CAJ | 학술논문

目的比较卡维地洛、比索洛尔治疗慢性心力衰竭(CHF)的疗效.方法 80例CHF患者分为卡维地洛组(40例)、比索洛尔组(40例),两组在常规治疗基础上分别加用卡维地洛和比索洛尔,观察治疗前后心率(HR)、血压(BP)、左心室舒张末径(LVEDD)、左心室收缩末径(LVESD)、左心室射血分数(LVEF)、6 min步行试验距离(6 min walk)等指标.结果卡维地洛组和比索洛尔组总有效率分别为82.5%和87.5%,两组差异无统计学意义(χ2=2.18,P＞0.05);治疗后两组HR、SBP、DBP、LVEDD、LVESD均低于治疗前(均P＜0.05);LVEF和6 min walk均高于治疗前(均P＜0.05).结论比索洛尔和卡维地洛疗效相似,均能显著改善心力衰竭患者的心功能.
목적 비교잡유지락、비색락이치료만성심력쇠갈(CHF)적료효.방법 80례CHF환자분위잡유지락조(40례)、비색락이조(40례),량조재상규치료기출상분별가용잡유지락화비색락이,관찰치료전후심솔(HR)、혈압(BP)、좌심실서장말경(LVEDD)、좌심실수축말경(LVESD)、좌심실사혈분수(LVEF)、6 min보행시험거리(6 min walk)등지표.결과 잡유지락조화비색락이조총유효솔분별위82.5%화87.5%,량조차이무통계학의의(χ2=2.18,P＞0.05);치료후량조HR、SBP、DBP、LVEDD、LVESD균저우치료전(균P＜0.05);LVEF화6 min walk균고우치료전(균P＜0.05).결론 비색락이화잡유지락료효상사,균능현저개선심력쇠갈환자적심공능.
Objective To compare the effects of Carvedilol.Bisoprolol therapies for patients with chronic heart failure(CHF). Methods 80 patients with CHF were divided into carvedilol group(40 cases) ,Bisoprolol group (40 cases) ;The two groups were treated respectively with Carvedilol or Bisoprolol in addition to the above conventional therapy. The indicators of heart rate( HR),blood pressure( BP) ,left ventricular end-diastolic diameter( LVEDD) , left ventricular end-systolic diameter( LVESD) ,left ventricular ejection fraction(LVEF) ,6min walking test distance (6min walk) were observed after treatment and before treatment. Results Total effective rates were 82.5% and 87.5% in Carvedilol group and the Bisoprolol group,There was no statistically significant difference between two groups(χ2 =2. 18,P>0.05) ;The indicators of HR,SBP,DBP,LVEDD,LVESD after treatment were lower than before treatment ( all P < 0.05); LVEF, and 6min walk were higher than before treatment (all P < 0.05). Conclusion Bisoprolol and Carvedilol could significantly improve cardiac function in patients with heart failure.