CAJ | 학술논문

目的研究在不同磁场强度条件下磁热籽阵列的热场分布与升温规律.方法单纯琼脂模体实验:在体积10 cm×10 cm×10 cm琼脂体模内分别按照直径3.0 cm、体积3.0 cm×3.0 cm ×2.6 cm和直径5.0 cm、体积5.0 cm×5.0 cm×2.6 cm的圆柱体阵列植入磁热籽.将其置于频率为100 kHz的交变磁场中,磁场强度从60 Gs开始按5 Gs分档直至120 Gs,依次实施分档升温测定实验.离体肌肉一琼脂混合模体实验:以不规则形琼脂体模模拟肿瘤靶区,分别使用90 Gs和120 Gs的磁场强度实施升温实验和温度场测量.结果单纯琼脂体模升温实验显示40 min的加热时间内不同直径圆柱体区域内植人磁热籽阵列中心点的最终温度随磁场强度增大而相应提高,升温至50℃的时间相应缩短,升温规律相同.离体肌肉-琼脂混合体模的升温热场分析显示不同磁场强度下磁热籽植入密度与靶区内的升温关系密切,热场均匀度与植入磁热籽密度和分布相关.结论磁场强度对磁热籽升温影响明显;在磁场达到一定强度后对磁热籽的升温影响减弱.提高磁场强度只在一定程度上对磁热籽加热有益;温度场分布与磁场强度和磁热籽植入密度关系密切.欲达到处方温度,低中磁场强度磁热籽植入密度较中高磁场强度时要密;在一定体积区域内需有足够的磁热籽密度方能达到处方温度值;磁热籽按照一定排序才能使温度场分布均匀,并非简单有序排布,但基本符合外密内疏的大原则.
목적 연구재불동자장강도조건하자열자진렬적열장분포여승온규률.방법 단순경지모체실험:재체적10 cm×10 cm×10 cm경지체모내분별안조직경3.0 cm、체적3.0 cm×3.0 cm ×2.6 cm화직경5.0 cm、체적5.0 cm×5.0 cm×2.6 cm적원주체진렬식입자열자.장기치우빈솔위100 kHz적교변자장중,자장강도종60 Gs개시안5 Gs분당직지120 Gs,의차실시분당승온측정실험.리체기육일경지혼합모체실험:이불규칙형경지체모모의종류파구,분별사용90 Gs화120 Gs적자장강도실시승온실험화온도장측량.결과 단순경지체모승온실험현시40 min적가열시간내불동직경원주체구역내식인자열자진렬중심점적최종온도수자장강도증대이상응제고,승온지50℃적시간상응축단,승온규률상동.리체기육-경지혼합체모적승온열장분석현시불동자장강도하자열자식입밀도여파구내적승온관계밀절,열장균균도여식입자열자밀도화분포상관.결론 자장강도대자열자승온영향명현;재자장체도일정강도후대자열자적승온영향감약.제고자장강도지재일정정도상대자열자가열유익;온도장분포여자장강도화자열자식입밀도관계밀절.욕체도처방온도,저중자장강도자열자식입밀도교중고자장강도시요밀;재일정체적구역내수유족구적자열자밀도방능체도처방온도치;자열자안조일정배서재능사온도장분포균균,병비간단유서배포,단기본부합외밀내소적대원칙.
Objective To study the laws of heating and thermal field of heating seed arrays in different magnetic field intensity during the magnetic induction hyperthermia.Methods 3.0 cm×3.0 cm ×2.6 cm and 5.0 cm ×5.0 cm×2.6 cm of magnetic heating seed was implanted respectively in 10.0 cm×10.0 cm ×10.0 cm pure agar phantom.The regions was divided into one file per 5 Gs in the range of 60-120 Gs magnetic induction.The temperature measurement experiments were implemented in each sub-file.Muscle-agar mixture model was used in the magnetic induction 60 Gs and 90 Gs to implement GTV-heating simulation experiments and thermal field analysis.Results The pure agar phantom heating experiments show that the heating is of basically the same rule when seeds with various diameters were implanted in the magnetic thermal array.Along with the increase of magnetic induction,the final temperature of the focal point heated for 40 min increased accordingly.and time required for heating to 50℃ was shortened correspondingly.The thermal field analysis of muscle-a mixture agar mixture model showed that the implantation density of magnetic heating seed is closely associated with the temperature of the target area and thermal field in difierent magnetic field intcnsity.Conclusions The magnetic induction has a significant impact on heating of the seeds,as the magnetic modium,and this impact is trending downwards when the magnetic field reaches a certain intensity.Within a certain size,adequate magnetic heating seed density is necessary to achieve the desired temperature required for the temperature value.The heating seeds should be put in a certain order to heat the venue evenly,not in a simply order,but in line with the principle of outer dense and inner sparse.