中华流行病学杂志
中華流行病學雜誌
중화류행병학잡지
CHINESE JOURNAL OF EPIDEMIOLOGY
2010年
3期
300-303
,共4页
姜仁杰%覃新程%金加洪%张红军%李明慧%沈进进%陈昌标%陈胤忠%吴斌%张永振
薑仁傑%覃新程%金加洪%張紅軍%李明慧%瀋進進%陳昌標%陳胤忠%吳斌%張永振
강인걸%담신정%금가홍%장홍군%리명혜%침진진%진창표%진윤충%오빈%장영진
狂犬病%流行病学
狂犬病%流行病學
광견병%류행병학
Rabies%Epidemiology
目的 分析盐城市狂犬病的流行病学特征.方法 收集狂犬病疫情资料,开展犬密度、犬免疫率、犬伤人率及狂犬病处置门诊工作调查;检测犬脑中狂犬病毒并进行相关分子生物学研究.结果 1999-2008年盐城市共报告135例人狂犬病,形成自1958年以来的第二次流行高峰,其中2003年报告40例狂犬病.135例患者中114例为农民.监测点调查发现盐城市犬密度为每100人中约豢养犬3～6只,每年平均100只犬伤人6.37人次,2008年犬的免疫率只有20%,暴露人群狂犬病疫苗接种率为77%.狂犬病处置门诊中抗狂犬病血清(球蛋白)的使用率仅为5%～10%.在采集108份犬脑标本中,4份狂犬病毒阳性,扩增、测序并分析病毒的N和G基因显示,这些病毒为基因Ⅰ型狂犬病毒,与目前使用的狂犬疫苗株CTN同源性最高.结论 盐城市人间狂犬病的持续流行与当地犬的饲养量大、免疫率低以及农村地区群众受动物伤害后的处理不及时规范及处理率低密切相关.
目的 分析鹽城市狂犬病的流行病學特徵.方法 收集狂犬病疫情資料,開展犬密度、犬免疫率、犬傷人率及狂犬病處置門診工作調查;檢測犬腦中狂犬病毒併進行相關分子生物學研究.結果 1999-2008年鹽城市共報告135例人狂犬病,形成自1958年以來的第二次流行高峰,其中2003年報告40例狂犬病.135例患者中114例為農民.鑑測點調查髮現鹽城市犬密度為每100人中約豢養犬3～6隻,每年平均100隻犬傷人6.37人次,2008年犬的免疫率隻有20%,暴露人群狂犬病疫苗接種率為77%.狂犬病處置門診中抗狂犬病血清(毬蛋白)的使用率僅為5%～10%.在採集108份犬腦標本中,4份狂犬病毒暘性,擴增、測序併分析病毒的N和G基因顯示,這些病毒為基因Ⅰ型狂犬病毒,與目前使用的狂犬疫苗株CTN同源性最高.結論 鹽城市人間狂犬病的持續流行與噹地犬的飼養量大、免疫率低以及農村地區群衆受動物傷害後的處理不及時規範及處理率低密切相關.
목적 분석염성시광견병적류행병학특정.방법 수집광견병역정자료,개전견밀도、견면역솔、견상인솔급광견병처치문진공작조사;검측견뇌중광견병독병진행상관분자생물학연구.결과 1999-2008년염성시공보고135례인광견병,형성자1958년이래적제이차류행고봉,기중2003년보고40례광견병.135례환자중114례위농민.감측점조사발현염성시견밀도위매100인중약환양견3～6지,매년평균100지견상인6.37인차,2008년견적면역솔지유20%,폭로인군광견병역묘접충솔위77%.광견병처치문진중항광견병혈청(구단백)적사용솔부위5%～10%.재채집108빈견뇌표본중,4빈광견병독양성,확증、측서병분석병독적N화G기인현시,저사병독위기인Ⅰ형광견병독,여목전사용적광견역묘주CTN동원성최고.결론 염성시인간광견병적지속류행여당지견적사양량대、면역솔저이급농촌지구군음수동물상해후적처리불급시규범급처리솔저밀절상관.
Objective To better understand the epidemiology of rabies during the past ten years in Yancheng city,Jiangsu province. Methods Data was collected and analyzed on rabies cases in Yancheng. Density and vaccination rate on Canine,Rate of injured people bit by dogs,and the information of post-exposure prophylaxis were studied. Rabies virus in the dog brains,collected around the epidemic areas of Yancheng,were detected and analyzed. Results A total of 135 human rabies cases occurred from 1999 through 2008,and formed the second epidemic peak since 1958. Of these victims,84% (114) were farmers. In general,the rate of people having dogs were 3%-6% per 100 people,and the injured person-times of 100 dogs were 6.37 per year. Notably,the vaccination rate of dogs was only 20%. Of those people injured by dogs and other animals,77% had received post-exposure treatment,and only 5%-10% had been administered anti-rabies serum. Rabies virus antigen was found in 4 (3.6%) of 111 brain specimens among dogs collected from epidemic areas. Genetic analysis of N and G genes,which were amplified from brain specimens,indicated that these viruses belong to genotype Ⅰ rabies and expressing a close relationship with the Chinese vaccine strain CTN. Conclusion The large number of dogs with low vaccination rate among them,together with the incorrect and low post-exposure treatment in rural areas seemed to be responsible for the outbreak of rabies in Yancheng city.
