CAJ | 학술논문

目的探讨壳聚糖护肤液促进伤口愈合的作用.方法在大鼠背部伤口模型上用药,对壳聚糖护肤液组(A组)、碱性成纤维细胞生长因子组(B组)、生理氯化钠溶液组(C组)进行两两对照,肉眼观察伤口愈合时间,并于伤后3、7、14d,取皮肤修复组织行光镜观察.结果 A组愈合时间为(17.3±1.35)d,B组为(18.2±1.15)d,C组为(24.0±1.37)d.A组与B组的愈合时间差异无统计学意义(P＞0.05),A组、B组与C组的愈合时间差异有统计学意义(P＜0.05)；壳聚糖护肤液在伤口愈合的早期促进毛细血管芽和血管内皮细胞生成,中期促进成纤维细胞和胶原纤维生成,后期使胶原纤维排列有序.结论壳聚糖护肤液具有较好的促进伤口愈合的作用.
목적 탐토각취당호부액촉진상구유합적작용.방법 재대서배부상구모형상용약,대각취당호부액조(A조)、감성성섬유세포생장인자조(B조)、생리록화납용액조(C조)진행량량대조,육안관찰상구유합시간,병우상후3、7、14d,취피부수복조직행광경관찰.결과 A조유합시간위(17.3±1.35)d,B조위(18.2±1.15)d,C조위(24.0±1.37)d.A조여B조적유합시간차이무통계학의의(P＞0.05),A조、B조여C조적유합시간차이유통계학의의(P＜0.05)；각취당호부액재상구유합적조기촉진모세혈관아화혈관내피세포생성,중기촉진성섬유세포화효원섬유생성,후기사효원섬유배렬유서.결론 각취당호부액구유교호적촉진상구유합적작용.
Objective To study the promotive effect of chitosan liquid on wound healing.Methods Wound model was established on the back of 60 rats,which were classified into 3 groups to be treated with topical chitosan liquid (group A),basic fibroblast growth factor (group B),and sodium chloride physiological solution (group C),respectively.The time required for the healing of wound was recorded.Regenerated tissues were resected from the rats on day 3,7 and 14 after the establishment of wound model,and observed with light microscopy.Results The time required for the healing of wound was 17.3 ± 1.35 days in group A,18.2 ± 1.15 days in group B,and 24.0 ± 1.37 days in group C.For the time required for the healing of wound,no significant difference was observed between the group A and B (P ＞ 0.05),but group C significantly differed from group A and B (both P ＜ 0.05).Chitosan liquid accelerated the generation of capillary sprouts and vascular endothelial cells at the early stage of wound healing,promoted the production of fibroblasts and collagen fibers at the middle stage,and improved the organization of collagen fibers at the late stage.Conclusion Chitosan liquid exerts a promising promotive effect on wound healing.