CAJ | 학술논문

目的探讨除幽门螺杆菌(Hp)感染和Barrett食管病变的关系.方法收集168例内镜检查患者的病历资料,其中Barrett食管患者86例(Barrett食管组),胃食管反流病(GRRD)患者51例(GERD组),食管黏膜的正常患者31例(对照组),采用快速尿素酶法和Warthin Starry银染两种染色方法检测各组患者Hp感染状态.结果对照组、GERD组和Barrett食管组Hp感染率分别为0、13.7%(7/51)和37.21%(32/86),Barrett食管组Hp感染率明显高于对照组和GERD组(X2=15.87,P<0.01;X2=10.94,P<0.01);Barrett食管中、重度炎症组Hp感染率明显高于轻度炎症组(X2=15.96,P<0.01);特殊肠化组Barrett食管Hp感染率略低于胃底和贲门型组,差异无统计学意义(P>0.05).结论 Hp感染与Barrett食管病变相关,Hp感染加重Barrett食管病变炎症程度.
목적 탐토제유문라간균(Hp)감염화Barrett식관병변적관계.방법 수집168례내경검사환자적병력자료,기중Barrett식관환자86례(Barrett식관조),위식관반류병(GRRD)환자51례(GERD조),식관점막적정상환자31례(대조조),채용쾌속뇨소매법화Warthin Starry은염량충염색방법검측각조환자Hp감염상태.결과 대조조、GERD조화Barrett식관조Hp감염솔분별위0、13.7%(7/51)화37.21%(32/86),Barrett식관조Hp감염솔명현고우대조조화GERD조(X2=15.87,P<0.01;X2=10.94,P<0.01);Barrett식관중、중도염증조Hp감염솔명현고우경도염증조(X2=15.96,P<0.01);특수장화조Barrett식관Hp감염솔략저우위저화분문형조,차이무통계학의의(P>0.05).결론 Hp감염여Barrett식관병변상관,Hp감염가중Barrett식관병변염증정도.
Objective To investigate the relation between Barrett esophagus(Barrett)and helicobacter pylori(Hp)infection.Methods One hundred and sixty eight patients were enrolled,including those affected by Barrett (n=86),gastreesophageal reflux disease(GERD n=51)and control group(n=31).Results The prevalence ofrate of Hp infection in Barrett was significantly higher than that in GERD control groups(X2=15.87.P<0.01;X2=10.94,P<0.01).The rate of Hp infection in the moderate and severe grade esophagitis was significantly higherthan that in the mild group(P<0.01).r11lle rate of Hp infection in the Barrett with intestinal metaplasia was lowerthan that in the Barrett group,but no significant difference was found.Conclusion Hp infection plays an important role in Barrett and its inflammation grades.