CAJ | 학술논문

目的探讨氯吡格雷对不稳定型心绞痛(UAP)患者血浆内皮素和降钙素基因相关肽的影响.方法将100例UAP患者随机分为两组,分别用消心痛(50例)及氯吡格雷加消心痛(50例)联合治疗,采用放免法观察治疗前后患者血浆内皮素(ET)及降钙素基因相关肽(CGRP)含量,另选20名健康体检者作对照.结果与健康志愿者相比,UAP患者血浆ET含量明显升高(P＜0.05),CGRP明显降低(P＜0.05).较消心痛治疗组相比,联合使用氯吡格雷治疗后患者ET明显下降(P＜0.01),CGRP明显升高(P＜0.05).结论氯吡格雷能显著改善ET、CGRP代谢失衡状况,是治疗UAP的有效药物.
목적 탐토록필격뢰대불은정형심교통(UAP)환자혈장내피소화강개소기인상관태적영향.방법 장100례UAP환자수궤분위량조,분별용소심통(50례)급록필격뢰가소심통(50례)연합치료,채용방면법관찰치료전후환자혈장내피소(ET)급강개소기인상관태(CGRP)함량,령선20명건강체검자작대조.결과 여건강지원자상비,UAP환자혈장ET함량명현승고(P＜0.05),CGRP명현강저(P＜0.05).교소심통치료조상비,연합사용록필격뢰치료후환자ET명현하강(P＜0.01),CGRP명현승고(P＜0.05).결론 록필격뢰능현저개선ET、CGRP대사실형상황,시치료UAP적유효약물.
Objective To investigate the effect of Clopidogrel on the plasma endothelin(ET)and calcitonin gene related peptide(CGRP)in patients with unstable angina pectoris(UAP).Methods Patients with UAP were divided into two groups,the regular treated group(n =50)was treated with Isoket and the Dansben group(n =50)was treated with combined Isoket and Clopidogrel.The plasma ET and CGRP were measured before and after treatment by radioimmunoreactive assay.Data were compared between the two groups and also compared with those measured in 20healthy subjects for control.Results ET level was significantly higher and CGRP level was lower in UAP patients than that in healthy subjects(P ＜ 0.05).After Clopidogrel treatment,ET was significantly decreased(P ＜ 0.01)and CGRP increased(P ＜0.05)in combined treatment group compared with patients received lsoket only.Conclusion Clopidogrel was an effective drug for UAP treatment,which could efficiently regulate the ET and CGRP metabolism.