CAJ | 학술논문

目的通过研究头面部婴儿型血管瘤57例60个瘤体的分布规律,糖转移蛋白-1(GLUT-1)表达,探索其发生机制.通过早期手术治疗,以期达到更好的治疗效果,预防严重并发症的发生.方法记录血管瘤的发生部位并统计各部位发生例数,对数据进行统计分析,找出面部血管瘤的分布规律,按照整形外科原则切除血管瘤,以免疫组化方法检测每个切除标本的GLUT-1表达.结果早期手术治疗效果满意,所有病例GLUT-1表达均为阳性,不同部位发生血管瘤的概率存在显著差异(P<0.05),其中上、下唇,眶周、面部中线部位发生的血管瘤占全部血管瘤的71.7%,即血管瘤的发生部位并非随机分布,而极易发生在胚胎发育过程中的面突融合部位.结论头面部的婴儿型血管瘤,可能是由于胎盘组织中的异常血管前体细胞回流入胎儿体内,并迁移、种植于面突融合部位继而发展成血管瘤.早期手术对于此类型血管瘤是较好的选择之一.
목적 통과연구두면부영인형혈관류57례60개류체적분포규률,당전이단백-1(GLUT-1)표체,탐색기발생궤제.통과조기수술치료,이기체도경호적치료효과,예방엄중병발증적발생.방법 기록혈관류적발생부위병통계각부위발생례수,대수거진행통계분석,조출면부혈관류적분포규률,안조정형외과원칙절제혈관류,이면역조화방법검측매개절제표본적GLUT-1표체.결과 조기수술치료효과만의,소유병례GLUT-1표체균위양성,불동부위발생혈관류적개솔존재현저차이(P<0.05),기중상、하진,광주、면부중선부위발생적혈관류점전부혈관류적71.7%,즉혈관류적발생부위병비수궤분포,이겁역발생재배태발육과정중적면돌융합부위.결론 두면부적영인형혈관류,가능시유우태반조직중적이상혈관전체세포회류입태인체내,병천이、충식우면돌융합부위계이발전성혈관류.조기수술대우차류형혈관류시교호적선택지일.
Objective To investigate the development, distribution and GLUT-1 expression of infantile hemangioma and to discuss the early surgical intervention for better results and avoiding severe complication. Methods The lesion site of each case was recorded and analyzed by SPSS V13.0 to study the distribution. The operation was guided by the principle of plastic surgery to remove the hemangioma. The GLUT-1 expression was detected by immunohistocbemical technique in all the resected samples. Results All the results were satisfactory. The GLUT-1 expression was positive in all the cases. The incidences in different sites were significantly different (P < 0.05). 71.7% of the hemangiomas were located at upper and lower lip, periorbital region and facial midline. It indicates that hemangioma is not randomly distributed. Most of them were located at the fusion of facial prominences during embryological development. Conclusions Infantile facial hemangioma maybe originated from endothelial progenitor cells of placenta which migrate and implant on the fusion of facial prominences. Early surgical intervention is one of the best choice for infantile facial hemangioma.