CAJ | 학술논문

目的:研究基因单核苷酸多态性与缺血性脑卒中的关系,寻找缺血性脑卒中发病的遗传易感基因.资料来源:应用计算机检索Medline 1980-2005年期间有关纤维蛋白原基因多态性与缺血性脑卒中的文献,检索词"stroke,Plasma Fibrinogen,polymorphism",并限定文章语言种类为英文.同时计算机检索中国科技期刊全文数据库1995-2005年期间纤维蛋白原基因多态性与缺血性脑卒中的文献,并限定文章语言种类为中文.检索词"缺血性脑卒中,纤维蛋白原,基因多态性",还通过与作者通信以获得全文等形式获得全文资料.资料选择:纳入文献只限于病例对照研究型论著,排除观察对比研究、经验总结、个案报告等文献.资料提炼:共检索到50余篇关于纤维蛋白原基因多态性与缺血性脑卒中的文献,20篇符合纳入标准,排除30余篇文献.资料综合:血浆纤维蛋白原水平受遗传和环境因素的共同作用,纤维蛋白原基因多态性对血浆纤维蛋白原水平起重要的调控作用,纤维蛋白原通过参与动脉粥样硬化和辅助血小板的聚集及改变血液流变学状态,促进血栓的形成使缺血性脑卒中的发病率增高.但是纤维蛋白原基因多态性的确切作用机制和分子功能还有待于进一步研究.结论:关于纤维蛋白原单核苷酸多态性与缺血性脑卒中的关系尚有争议,还需进一步的研究.
목적:연구기인단핵감산다태성여결혈성뇌졸중적관계,심조결혈성뇌졸중발병적유전역감기인.자료래원:응용계산궤검색Medline 1980-2005년기간유관섬유단백원기인다태성여결혈성뇌졸중적문헌,검색사"stroke,Plasma Fibrinogen,polymorphism",병한정문장어언충류위영문.동시계산궤검색중국과기기간전문수거고1995-2005년기간섬유단백원기인다태성여결혈성뇌졸중적문헌,병한정문장어언충류위중문.검색사"결혈성뇌졸중,섬유단백원,기인다태성",환통과여작자통신이획득전문등형식획득전문자료.자료선택:납입문헌지한우병례대조연구형론저,배제관찰대비연구、경험총결、개안보고등문헌.자료제련:공검색도50여편관우섬유단백원기인다태성여결혈성뇌졸중적문헌,20편부합납입표준,배제30여편문헌.자료종합:혈장섬유단백원수평수유전화배경인소적공동작용,섬유단백원기인다태성대혈장섬유단백원수평기중요적조공작용,섬유단백원통과삼여동맥죽양경화화보조혈소판적취집급개변혈액류변학상태,촉진혈전적형성사결혈성뇌졸중적발병솔증고.단시섬유단백원기인다태성적학절작용궤제화분자공능환유대우진일보연구.결론:관우섬유단백원단핵감산다태성여결혈성뇌졸중적관계상유쟁의,환수진일보적연구.
OBJECTIVE: To investigate the relationship between single nucleotide polymorphism of gene and ischemic stroke and search for predisposing genes of ischemic stroke.DATA SOURCES: The Medline database was searched for articles of gene polymorphism of fibrinogen and ischemic stroke published from 1980 to 2005 with the key words of "stroke, plasma fibrinogen, polymorphism"in English. Meanwhile, Vip Information Database was also searched for literatures of gene polymorphism of fibrinogen and schemic stroke published between 1995 and 2005 with the key terms of "ischemic stroke, fibrinogen,gene polymorphism" in Chinese. Full-texts were gotten by correspondence with the authors.STUDY SELECTION: Included literatures were only case control study literatures. Literatures of contrast study, experience summary, individual case and so on were excluded.DATA EXTRACTION: Totally 50 articles of gene polymorphism of fibrinogen and ischemic stroke were retrieved. Twenty articles were accorded with inclusive criteria, and thirty articles were excluded.DATA SYNTHESIS: Level of plasma fibrinogen was co-affected by heredity and environment. Gene polymorphism of fibrinogen has important regulatory effects on the level of plasma fibrinogen. The fibrinogen accelerates thrombotic formation. As a result, the incidence rate of ischemic stroke increased by participating atherosclerosis, helping thrombocytic aggregation and changing the status of hemorheology. But definite mechanism and molecular function of gene polymorphism of fibrinogen deserved further research.CONCLUSION: The relationship between single nucleotide polymorphism of fibrinogen and ischemic stroke remains obscure. It also needs further study.