颈腰痛杂志
頸腰痛雜誌
경요통잡지
2009年
4期
310-312
,共3页
椎间盘突出%重吸收%动物模型%新生血管%炎性反应
椎間盤突齣%重吸收%動物模型%新生血管%炎性反應
추간반돌출%중흡수%동물모형%신생혈관%염성반응
disc herniation%resorption%animal model%VEGF%inflammatory reaction
目的 探讨破裂型椎间盘突出后重吸过程中新生血管的长入与炎性反应的存在.方法 将20只SD雄性大鼠,经手术切除尾椎椎间盘.埋植在背部硬膜外.造成破裂型椎间盘突出模型.动物30d后处死,取埋植的髓核组织,进行HE染色,免疫组化检测.结果 30d后椎间盘组织的形态结构发生明显改变,椎间盘组织中新生血管与巨噬细胞的免疫组化染色均呈阳性.结论 破裂型椎间盘突出的髓核组织经过一段时间确实有新生血管的长入与炎性反应的存在,其可能在椎间盘突出重吸收过程中发挥重要作用.
目的 探討破裂型椎間盤突齣後重吸過程中新生血管的長入與炎性反應的存在.方法 將20隻SD雄性大鼠,經手術切除尾椎椎間盤.埋植在揹部硬膜外.造成破裂型椎間盤突齣模型.動物30d後處死,取埋植的髓覈組織,進行HE染色,免疫組化檢測.結果 30d後椎間盤組織的形態結構髮生明顯改變,椎間盤組織中新生血管與巨噬細胞的免疫組化染色均呈暘性.結論 破裂型椎間盤突齣的髓覈組織經過一段時間確實有新生血管的長入與炎性反應的存在,其可能在椎間盤突齣重吸收過程中髮揮重要作用.
목적 탐토파렬형추간반돌출후중흡과정중신생혈관적장입여염성반응적존재.방법 장20지SD웅성대서,경수술절제미추추간반.매식재배부경막외.조성파렬형추간반돌출모형.동물30d후처사,취매식적수핵조직,진행HE염색,면역조화검측.결과 30d후추간반조직적형태결구발생명현개변,추간반조직중신생혈관여거서세포적면역조화염색균정양성.결론 파렬형추간반돌출적수핵조직경과일단시간학실유신생혈관적장입여염성반응적존재,기가능재추간반돌출중흡수과정중발휘중요작용.
Objective To investigate the possible existence of VEGF and inflammatory reaction in the resorption of the intervertebral disc herniation. Methods 20male SD (Sprague-dawley)rats were chosen. The rats were divided into control group and experimental group at random. At the experimental group,discs was harvested from the caudal vertebrae and placed subcutaneously in the epidural. After 30 days,the rats were killed and discs were harvested. HE staining and immunohis-tochemistry were used for analysis of cells and tissue. Results As compared with the control group,the VEGF and inflammatory reaction were signifiantly existing. Conclusion VEGF and in-flammatory reaction maybe triggered an autoimmune response,and played an important role in the resorption of the intervertebral disc herniation.
