CAJ | 학술논문

GATA-2是对外胚层和中胚层发育至关重要的转录因子,它属于具有保守锌指结构的GATA转录因子家族.GATA家族包括6个成员:分别命名为GATA-1～GATA-6.最新研究表明,GATA-2不仅存在于胚胎器官,还对成体造血细胞系、神经系统、垂体和泌尿生殖系统中细胞的功能和维持都必不可少.本文旨在通过对GATA-2的功能研究进展进行综述,探讨GATA-2在生殖系统中的作用机制,以期更广泛地了解GATA-2基因在生物发育过程中的作用及对相关基因的调控机制,从而为攻克人类相关疾病提供理论依据.
GATA-2시대외배층화중배층발육지관중요적전록인자,타속우구유보수자지결구적GATA전록인자가족.GATA가족포괄6개성원:분별명명위GATA-1～GATA-6.최신연구표명,GATA-2불부존재우배태기관,환대성체조혈세포계、신경계통、수체화비뇨생식계통중세포적공능화유지도필불가소.본문지재통과대GATA-2적공능연구진전진행종술,탐토GATA-2재생식계통중적작용궤제,이기경엄범지료해GATA-2기인재생물발육과정중적작용급대상관기인적조공궤제,종이위공극인류상관질병제공이론의거.
GATA-2 transcription factor plays a critical role in the development of the ectoderm and mesoderm. It belongs to the GATA family, which contains 2 conserved zinc finger DNA-binding domains and is composed of six members, termed from GATA-1 to GATA-6. GATA-2 is present in embryonic tissues and organs and is also found in hematopoietic lineage cells, the nervous system, pituitary and genitourinary system, and is essential for the maintenance of their function in adults. The present review focuses on the critical roles of GATA-2 during the developmental process in vertebrates and tries to explore the molecular mechanism of its regulation in the reproductive system, so as to provide a theoretical basis for the human diseases related to GATA-2.