CAJ | 학술논문

肿瘤多药耐药是肿瘤治疗的难点,其产生机制错综复杂.经典的多药耐药机制涉及以下几个方面:多药耐药相关蛋白的高表达、酶系统的异常、细胞凋亡的抑制及基因修复异常.近年来发现肿瘤多药耐药还与肿瘤干细胞、肿瘤微环境及信号传导通路异常等关系密切.
종류다약내약시종류치료적난점,기산생궤제착종복잡.경전적다약내약궤제섭급이하궤개방면:다약내약상관단백적고표체、매계통적이상、세포조망적억제급기인수복이상.근년래발현종류다약내약환여종류간세포、종류미배경급신호전도통로이상등관계밀절.
The development of multidrug resistance (MDR) to chemotherapy remains a major trouble in the treatment of tumors,and the mechanisms of MDR are complicated.The classic mechanisms involve the overexpression of multidrug resistance-associated protein,inhibition of cell apoptosis,abnormality of enzyme system and gene repair.Studies in recent years have shown that the mechanisms of MDR are also closely related with tumor stem cells,tumor microenvironment and abnormality of signal transduction pathways.