CAJ | 학술논문

目的评价特发性黄斑裂孔(IMH)患眼和对侧健眼的黄斑部脉络膜厚度,并与年龄性别相匹配的正常人群比较,分析其临床意义.方法横断面分析研究.对2011年3～8月在中山眼科中心就诊的40例单眼IMH患者,分为患眼组(A组)40只眼,对侧健眼组(B组)38只眼；另设正常对照组(C组)40例40只眼为年龄、性别、屈光度匹配的正常成年人.采用海德馒Spcctralis频域OCT加强深度扫描(Enhanced Depth Imaging,EDI)测定中心凹下脉络膜厚度(Subfoveal choroidal thickness,SFCT)、距中心凹l mm和3 mm处上下鼻颞四方位脉络膜厚度(SCT1mm、SCT3mm、 ICT1mm、ICT3mm、NCT1mm、NCT3mm、TCT1mm、TCT3mm、).结果单眼IMH患者,配对t检验显示患眼SFCT值较对侧健眼变薄,t =-3.906,P＜0.001.三组间比较,A组、B组和C组SFCT均值分别为(214.82±66.67)μm,(243.53±76.67) μm和(259.87±64.39) μm,A组较C组明显降低.B组较C组降低,但差异无统计学意义.结论 IMH患眼中脉络膜厚度变薄明显,可能与其发病机制有关.对侧健眼的脉络膜厚度较正常对照组亦有降低,提示脉络膜血管代谢功能下降,可能是IMH发病的因素之一.
목적 평개특발성황반렬공(IMH)환안화대측건안적황반부맥락막후도,병여년령성별상필배적정상인군비교,분석기림상의의.방법 횡단면분석연구.대2011년3～8월재중산안과중심취진적40례단안IMH환자,분위환안조(A조)40지안,대측건안조(B조)38지안；령설정상대조조(C조)40례40지안위년령、성별、굴광도필배적정상성년인.채용해덕만Spcctralis빈역OCT가강심도소묘(Enhanced Depth Imaging,EDI)측정중심요하맥락막후도(Subfoveal choroidal thickness,SFCT)、거중심요l mm화3 mm처상하비섭사방위맥락막후도(SCT1mm、SCT3mm、 ICT1mm、ICT3mm、NCT1mm、NCT3mm、TCT1mm、TCT3mm、).결과 단안IMH환자,배대t검험현시환안SFCT치교대측건안변박,t =-3.906,P＜0.001.삼조간비교,A조、B조화C조SFCT균치분별위(214.82±66.67)μm,(243.53±76.67) μm화(259.87±64.39) μm,A조교C조명현강저.B조교C조강저,단차이무통계학의의.결론 IMH환안중맥락막후도변박명현,가능여기발병궤제유관.대측건안적맥락막후도교정상대조조역유강저,제시맥락막혈관대사공능하강,가능시IMH발병적인소지일.
Objective To determine the choroidal thickness in the macular area in affected and unaffected fellow eyes with idiopathic macular hole (IMH) and in healthy controls. Methods Forty patients with unilateral IMH and 40 controls were recruited in this observational cross-sectional study.All eyes were divided into three groups:40 eyes in Group A (affected eyes with IMH),38eyes in Group B (unaffected fellow eyes) and 40 eyes in Group C (right eyes of age- and sex-matched controls).Enhanced depth imaging was obtained by using spectral-domain optical coherence tomography.Subfoveal choroidal thickness (SFCT) and choroidal thickness at lmm/3mm superior,inferior,nasal,and temporal to the fovea were measured. Results Choroidal thickness was significantly decreased in affected eyes with IMH than that in unaffected fellow eyes in 38 patients (P ＜0.001,paired-t-test).The mean subfoveal choroidal thickness (SFCT) was 214.82±66.67μm in Group A,243.53±76.67μm in Group B,and 259.87±64.39μm in Group C.The subfoveal choroid was significantly thinner in Group A than that in Group C (P =0.005).SFCT in unaffected fellow eyes were lower than that in controls,but without statistical significance. Conclusions Choroidal thickness is thinner in affected eyes with IMH and also in fellow unaffected eyes.This may suggest a contributing role of the perfusion of the choroid in the pathogenesis of IMH.The fellow eyes with thinner choroid may be prone to IMH and should be followed-up frequently.